| Anaesthesia for an adult with Angelman syndrome. | |
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MedLine Citation:
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PMID: 19825063 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Angelman syndrome is a complex genetic condition involving abnormalities of chromosome 15 in the majority of cases. These defects involve a gene encoding an ubiquitin protein ligase and may be associated with abnormal gamma-aminobutyric acid (GABA)(A) receptor subunits. Angelman syndrome may have profound implications for anaesthesia: potential exists for airway difficulties; refractory bradyarrythmias; and pharmacodynamic unpredictability. A case of an adult with Angelman syndrome undergoing dental work under general anaesthesia is presented. Induction and maintenance of anaesthesia was unremarkable but emergence was complicated by generalised muscular hypertonia and temporary respiratory embarrassment which resolved spontaneously. |
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Authors:
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M Maguire |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Anaesthesia Volume: 64 ISSN: 1365-2044 ISO Abbreviation: Anaesthesia Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-10-14 Completed Date: 2009-11-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370524 Medline TA: Anaesthesia Country: England |
Other Details:
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Languages: eng Pagination: 1250-3 Citation Subset: AIM; IM |
Affiliation:
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Department of Anaesthesia and Perioperative Medicine, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia. marc_maguire@health.qld.gov.au |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anesthesia, General / methods* Angelman Syndrome / complications* Dental Care* Female Humans Muscle Hypertonia / etiology Respiratory Insufficiency / etiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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