Document Detail

Anaerobic threshold in total artificial heart animals.
MedLine Citation:
PMID:  8555535     Owner:  NLM     Status:  MEDLINE    
The anaerobic threshold represents an objective measure of functional capacity and is useful in assessment of pulmonary and cardiovascular dysfunction. This study determined the anaerobic threshold in total artificial heart animals and evaluated the performance of the total artificial heart system. Five animals with total artificial hearts were put under incremental exercise testing after exercise training. The intensity of exercise ranged from 2.0 to 4.5 km/hr, with an increment of 0.5 km/hr every 3 min. The anaerobic threshold was 6.72 +/- 0.84 ml/kg/min as detected by the lactate method, and 6.48 +/- 0.79 by the CO2 method. The value of the anaerobic threshold in total artificial heart animals implies that the performance capacity of a total artificial heart is not sufficient to meet the oxygen requirements of vigorously exercising skeletal muscle. The protocol does not allow for driving parameter changes during exercise, and this situation, combined with the manual mode of the control system used, was inadequate to allow the total artificial heart animals to exercise more vigorously. Using an automatic control mode might be helpful, as well as considering the relationship between indices of oxygen metabolism, such as oxygen delivery, oxygen consumption, and oxygen extraction rate, in the control algorithms in total artificial heart control systems.
B Y Chiang; G Pantalos; G L Burns; J W Long; P S Khanwilkar; S D Everett; S F Mohammad; D B Olsen
Related Documents :
18599385 - Breath-by-breath changes of lung oxygen stores at rest and during exercise in humans.
2289985 - Practical points in the application of oxygen transport principles.
12049845 - Reductive activation of terpenylnaphthoquinones.
9510525 - Mitochondrial oxygen affinity, respiratory flux control and excess capacity of cytochro...
12915785 - Truncating the dose range for methacholine challenge tests: three occupational studies.
3304705 - Nitrate tolerance: the lack of effect of n-acetylcysteine.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  ASAIO journal (American Society for Artificial Internal Organs : 1992)     Volume:  40     ISSN:  1058-2916     ISO Abbreviation:  ASAIO J.     Publication Date:    1994 Jul-Sep
Date Detail:
Created Date:  1996-02-26     Completed Date:  1996-02-26     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9204109     Medline TA:  ASAIO J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  M335-8     Citation Subset:  IM    
Artificial Heart Research Laboratory, University of Utah, Salt Lake City 84103-1414, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anaerobic Threshold / physiology*
Blood Pressure / physiology
Carbon Dioxide / blood
Cardiac Output / physiology
Evaluation Studies as Topic
Heart, Artificial*
Lactates / blood
Lactic Acid
Oxygen / blood
Oxygen Consumption / physiology
Physical Exertion / physiology
Reg. No./Substance:
0/Lactates; 124-38-9/Carbon Dioxide; 50-21-5/Lactic Acid; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Myocardial tolerance to mechanical actuation is affected by biomaterial characteristics.
Next Document:  Efficacy of extracorporeal life support in the setting of adult cardiorespiratory failure.