| Anaerobic exercise causes transient changes in leukocyte subsets and IL-2R expression. | |
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MedLine Citation:
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PMID: 1470015 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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There is evidence that the stress of intense athletic competition and training depresses cellular immunity and predisposes athletes to increased infection. This paper reports changes in circulating leukocyte subsets of trained (group I: VO2max = 67.2 +/- 5.4 ml.kg-1min-1; age = 22.0 +/- 6.2 yr) and untrained (group II: VO2max = 55.0 +/- 4.9 ml.kg-1min-1; age = 21.4 +/- 2.0 yr) males following 1 min of bicycle ergometry at maximum effort. Significant post-exercise increases in concentrations of total leukocytes, monocytes, lymphocytes, CD3+, CD4+, CD8+ lymphocytes were observed in both groups (all P < 0.01). The CD4/CD8 ratio decreased significantly (P < 0.01) but the granulocyte concentration was not altered (P > 0.05). Despite groups I and II not differing in either peak power or total work performed during the exercise test (P > 0.05), group II had a significantly greater concentration and percentage of CD8+ lymphocytes immediately after exercise (P < 0.01). All of the early changes were transient, with normalization occurring within 1 h. Only trained subjects showed a significant decrease in the percentage of CD25+ lymphocytes following PHA stimulation of whole blood obtained 6 h post-exercise. Alterations in leukocyte subpopulations found in response to predominantly anaerobic exercise appear to be associated with a significant, but possibly transient, alteration in the mitogenic responsiveness of lymphocytes that is restricted to aerobically trained subjects. |
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Authors:
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A B Gray; Y C Smart; R D Telford; M J Weidemann; T K Roberts |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Medicine and science in sports and exercise Volume: 24 ISSN: 0195-9131 ISO Abbreviation: Med Sci Sports Exerc Publication Date: 1992 Dec |
Date Detail:
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Created Date: 1993-01-27 Completed Date: 1993-01-27 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8005433 Medline TA: Med Sci Sports Exerc Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1332-8 Citation Subset: IM; S |
Affiliation:
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Department of Biological Sciences, University of Newcastle, NSW, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Antigens, CD3 / blood Antigens, CD4 / blood Antigens, CD8 / blood Exercise / physiology* Exercise Test Humans Lactates / blood* Leukocyte Count Lymphocyte Subsets / immunology* Male Physical Fitness / physiology Receptors, Interleukin-2 / metabolism* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD3; 0/Antigens, CD4; 0/Antigens, CD8; 0/Lactates; 0/Receptors, Interleukin-2 |
| Comments/Corrections | |
Erratum In:
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Med Sci Sports Exerc 1993 Apr;25(4):535 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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