Document Detail

Anaerobic (bacterial) vaginosis and premalignant disease of the cervix.
MedLine Citation:
PMID:  15511897     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Nitrosamines are carcinogenic substances found in cigarette smoke, and it is known that female smokers have an increased risk of cervical carcinoma and premalignant change. Nitrosamines may also be formed due to the combination of amines and nitrites in an acidic medium. This study has shown a statistically significant association between anaerobic vaginosis which produce amines and cervical intraepithelial neoplasia 2 and 3. In addition nitrate reducing organisms are found in the acidic lower genital tract in a significant number of cases. It is therefore theoretically possible that nitrosamines may be an important agent in the development of premalignant disease of the cervix.
J W Barrington; D Linton; A O'Leary; A Blackwell; J Brick; J P Calvert
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology     Volume:  17     ISSN:  0144-3615     ISO Abbreviation:  J Obstet Gynaecol     Publication Date:  1997 Jun 
Date Detail:
Created Date:  2004-10-29     Completed Date:  2005-04-21     Revised Date:  2005-04-25    
Medline Journal Info:
Nlm Unique ID:  8309140     Medline TA:  J Obstet Gynaecol     Country:  England    
Other Details:
Languages:  eng     Pagination:  383-5     Citation Subset:  -    
Department of Obstetrics and Gynaecology, Singleton Hospital, Swansea, UK.
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Comment In:
J Obstet Gynaecol. 1998 Mar;18(2):207; author reply 207   [PMID:  15512059 ]

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