Document Detail

Anaemia of prematurity: treatment with erythropoietin.
MedLine Citation:
PMID:  11755036     Owner:  NLM     Status:  MEDLINE    
Anemia of prematurity is a hyporegenerative anemia usually appearing after the second week, reaching highest intensity in the second month of life. It's normocytic and normochromic with low reticulocyte count. It has been attributed to EPO deficiency. The low EPO levels detected in premature infants and the proper response to synthetic erythropoietin suggested that EPO administration in premature of < or =32 weeks gestational age could be of benefit trying to maintain or increase the hematocrit levels. Protocols of EPO administration to premature babies should always be considered as EPO+Fe, keeping ferritin levels over 100 ng/ml. Failures to EPO+Fe treatment in very small premature babies, measured as no decrease in the need of blood transfusions, may be due to the amount of blood looses that should be restricted.
X Carbonell-Estrany; J Figueras-Aloy
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Early human development     Volume:  65 Suppl     ISSN:  0378-3782     ISO Abbreviation:  Early Hum. Dev.     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-12-28     Completed Date:  2002-02-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7708381     Medline TA:  Early Hum Dev     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  S63-7     Citation Subset:  IM    
Neonatology Service, Hospital Clinic, Institut Clinic de Ginecología, Obstetricia I Neonatologia, Unitat Integrada, Universitat de Barcelona, Barcelona, Spain.
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MeSH Terms
Anemia, Neonatal / drug therapy*
Erythropoietin / administration & dosage,  therapeutic use*
Ferritins / blood
Gestational Age
Infant, Newborn
Infant, Premature*
Iron / administration & dosage,  therapeutic use
Reg. No./Substance:
11096-26-7/Erythropoietin; 7439-89-6/Iron; 9007-73-2/Ferritins

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