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Anaemia is an independent predictor of mortality in patients with left ventricular systolic dysfunction following acute myocardial infarction.
MedLine Citation:
PMID:  16678485     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: In patients with chronic heart failure (HF), mortality is inversely related to haemoglobin (hgb) concentration. We investigated the prognostic importance of anaemia in patients with acute myocardial infarction (AMI) and left ventricular systolic dysfunction (LVSD) with and without HF.
METHODS AND RESULTS: We studied 1731 patients with AMI and left ventricular ejection fraction </=35% from the TRAndolapril Cardiac Evaluation (TRACE) study. Mild anaemia (110 g/L</=hgb<120 g/L in women and 120 g/L</=hgb<130 g/L in men) was present in 264 patients (15%), 114 (7%) had moderate (100 g/L</=hgb<110 g/L in women and 110 g/L</=hgb<120 g/L in men) and 59 (3%) had severe (hgb <100 g/L in women and <110 g/L in men) anaemia. According to the WHO criteria (hgb </=120 g/L in women and <130 g/L in men), 25% had anaemia. Anaemia was associated with increasing age, higher serum creatinine, lower body mass index, history of chronic HF, and worse NYHA class. In multivariable analyses including other prognostic factors only severe anaemia was associated with increased mortality, hazard ratio 1.59 (1.20-2.11). Anaemia was of prognostic importance in patients with HF, but not without HF. In HF patients the hazard ratios were 1.73 (1.26-2.36), 1.20 (0.93-1.56) and 1.05 (0.88-1.25) for severe, moderate and mild anaemia, respectively.
CONCLUSION: Anaemia is an independent predictor of mortality in patients with AMI and LVSD, but prognostic importance of anaemia is confined to the first year following AMI. The increased risk is driven by patients with severe anaemia and HF.
Authors:
Nana Valeur; Olav Wendelboe Nielsen; John J V McMurray; Christian Torp-Pedersen; Lars Køber;
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-05-05
Journal Detail:
Title:  European journal of heart failure     Volume:  8     ISSN:  1388-9842     ISO Abbreviation:  Eur. J. Heart Fail.     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-10-23     Completed Date:  2007-02-27     Revised Date:  2011-06-08    
Medline Journal Info:
Nlm Unique ID:  100887595     Medline TA:  Eur J Heart Fail     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  577-84     Citation Subset:  IM    
Affiliation:
Department of Cardiology, Rigshospitalet, Copenhagen, Denmark.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adult
Aged
Aged, 80 and over
Anemia / etiology*,  mortality
Female
Humans
Male
Middle Aged
Myocardial Infarction / complications*,  mortality
Prognosis
Retrospective Studies
Systole
Time Factors
Ventricular Dysfunction, Left / etiology*,  mortality

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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