| Anaemia is an independent predictor of death in patients hospitalized for acute heart failure. | |
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MedLine Citation:
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PMID: 19921298 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Acute heart failure is associated with a poor prognosis. It is important to identify patients at increased risk of adverse events. The presence of anaemia could help in this regard. METHODS AND RESULTS: Admission charts of 627 patients (325 female) with acute heart failure were analysed; 182 patients (29%) fulfilled the World Health Organization criteria of anaemia [haemoglobin (Hb) < 13.0 in men, <12.0 g/dl in women], 87 (48%) of them were female. Anaemic patients were older than non-anaemics (p = 0.04), had lower systolic and diastolic blood pressure (both p < 0.05), had higher creatinine (p < 0.01), and stayed longer in hospital (p = 0.0005). Patients were followed-up for a mean of 61 months or until death. A total of 387 patients (61.7%) died during follow-up. Anaemia was an independent predictor of death in this cohort. Patients with moderate or severe anaemia (Hb < 12 in men or <11 g/dl in women) had a significantly increased 12-month mortality after adjusting for age, New York Heart Association class, systolic and diastolic blood pressure, and creatinine (hazard ratio 1.5, 95% confidence interval 1.1-2.0, p = 0.01). CONCLUSION: Anaemia is a frequent co-morbidity in patients with acute heart failure. Moderate to severe anaemia is an independent predictor of death in these patients. |
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Authors:
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Stephan von Haehling; Joerg C Schefold; Lea Majc Hodoscek; Wolfram Doehner; Marwan Mannaa; Stefan D Anker; Mitja Lainscak |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical research in cardiology : official journal of the German Cardiac Society Volume: 99 ISSN: 1861-0692 ISO Abbreviation: Clin Res Cardiol Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-17 Completed Date: 2010-05-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101264123 Medline TA: Clin Res Cardiol Country: Germany |
Other Details:
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Languages: eng Pagination: 107-13 Citation Subset: IM |
Affiliation:
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Applied Cachexia Research, Department of Cardiology, Charit? Medical School, Campus Virchow-Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany. stephan.von.haehling@web.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Aged Anemia / diagnosis*, mortality* Comorbidity Female Germany / epidemiology Heart Failure / diagnosis*, mortality* Humans Incidence Male Patient Admission / statistics & numerical data* Proportional Hazards Models* Risk Assessment Risk Factors Survival Analysis Survival Rate |
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