Document Detail

Anaemia is an independent predictor of death in patients hospitalized for acute heart failure.
MedLine Citation:
PMID:  19921298     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Acute heart failure is associated with a poor prognosis. It is important to identify patients at increased risk of adverse events. The presence of anaemia could help in this regard. METHODS AND RESULTS: Admission charts of 627 patients (325 female) with acute heart failure were analysed; 182 patients (29%) fulfilled the World Health Organization criteria of anaemia [haemoglobin (Hb) < 13.0 in men, <12.0 g/dl in women], 87 (48%) of them were female. Anaemic patients were older than non-anaemics (p = 0.04), had lower systolic and diastolic blood pressure (both p < 0.05), had higher creatinine (p < 0.01), and stayed longer in hospital (p = 0.0005). Patients were followed-up for a mean of 61 months or until death. A total of 387 patients (61.7%) died during follow-up. Anaemia was an independent predictor of death in this cohort. Patients with moderate or severe anaemia (Hb < 12 in men or <11 g/dl in women) had a significantly increased 12-month mortality after adjusting for age, New York Heart Association class, systolic and diastolic blood pressure, and creatinine (hazard ratio 1.5, 95% confidence interval 1.1-2.0, p = 0.01). CONCLUSION: Anaemia is a frequent co-morbidity in patients with acute heart failure. Moderate to severe anaemia is an independent predictor of death in these patients.
Stephan von Haehling; Joerg C Schefold; Lea Majc Hodoscek; Wolfram Doehner; Marwan Mannaa; Stefan D Anker; Mitja Lainscak
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical research in cardiology : official journal of the German Cardiac Society     Volume:  99     ISSN:  1861-0692     ISO Abbreviation:  Clin Res Cardiol     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-17     Completed Date:  2010-05-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101264123     Medline TA:  Clin Res Cardiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  107-13     Citation Subset:  IM    
Applied Cachexia Research, Department of Cardiology, Charit? Medical School, Campus Virchow-Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany.
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MeSH Terms
Acute Disease
Anemia / diagnosis*,  mortality*
Germany / epidemiology
Heart Failure / diagnosis*,  mortality*
Patient Admission / statistics & numerical data*
Proportional Hazards Models*
Risk Assessment
Risk Factors
Survival Analysis
Survival Rate

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