Document Detail


Anaemia in rheumatoid arthritis: pathogenesis, diagnosis and treatment.
MedLine Citation:
PMID:  2180049     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The pathogenesis, diagnosis and treatment of the anaemia of chronic disorders (ACD) in rheumatoid arthritis (RA) were reviewed. Causes of anaemia other than ACD frequently present in RA. Decreased iron absorption was shown to be the result of active RA rather than a cause of ACD or iron deficiency. It has been hypothesized that bone marrow iron availability decreases due to decreased iron release by the mononuclear phagocyte system or that the anaemia in ACD is due to ineffective erythropoiesis; these remain controversial theories. Studies considering a decreased erythropoietin responsiveness have not produced consistent results. Erythroid colony growth is suppressed in vitro by interleukins and tumour necrosis factor but their role in vivo in ACD is unknown. The diagnosis of ACD is made by exclusion. Iron deficiency is detected by transferrin, ferritin, and cellular indices after adaptation of their normal values. Treatment of the anaemia consists merely of antirheumatic treatment. Iron administration is counterproductive since iron chelators or exogenous erythropoietin administration might increase erythropoiesis.
Authors:
G Vreugdenhil; A J Swaak
Related Documents :
8581569 - Infectious and lymphocytic myocarditis: epidemiology and factors relevant to sports med...
11531039 - An exploratory study into the effect of exhausting bicycle exercise on endocrine and im...
16410379 - Sex-based effects on the distribution of nk cell subsets in response to exercise and ca...
18206729 - Effects of exercise on hematological parameters, circulating side population cells, and...
11710669 - The immune response to resistance exercise.
7791579 - Guidelines, standards, and perspectives in exercise immunology.
6349619 - Sensitivity to insulin of glycolysis and glycogen synthesis of isolated soleus-muscle s...
9066829 - Airway reactivity induced reversible voice dysfunction in singers.
18289809 - Breath-synchronized plume-control inhaler for pulmonary delivery of fluticasone propion...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Rheumatology international     Volume:  9     ISSN:  0172-8172     ISO Abbreviation:  Rheumatol. Int.     Publication Date:  1990  
Date Detail:
Created Date:  1990-04-17     Completed Date:  1990-04-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8206885     Medline TA:  Rheumatol Int     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  243-57     Citation Subset:  IM    
Affiliation:
Zuiderziekenhuis, Department of Internal Medicine, Rotterdam, The Netherlands.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Absorption
Anemia / diagnosis,  etiology*,  therapy
Arthritis, Rheumatoid / complications*
Cell Survival
Diagnosis, Differential
Erythrocytes / physiology
Erythropoiesis
Erythropoietin / blood
Ferritins / physiology
Hemolysis
Humans
Iron / pharmacokinetics
Lactoferrin / physiology
Phagocytes / physiology
Stem Cells / physiology
Chemical
Reg. No./Substance:
0/Lactoferrin; 11096-26-7/Erythropoietin; 7439-89-6/Iron; 9007-73-2/Ferritins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Gastrinoma.
Next Document:  Stress (heat shock) proteins and rheumatic disease. New advance or just another band wagon?