| Anaemia in rheumatoid arthritis: pathogenesis, diagnosis and treatment. | |
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MedLine Citation:
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PMID: 2180049 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The pathogenesis, diagnosis and treatment of the anaemia of chronic disorders (ACD) in rheumatoid arthritis (RA) were reviewed. Causes of anaemia other than ACD frequently present in RA. Decreased iron absorption was shown to be the result of active RA rather than a cause of ACD or iron deficiency. It has been hypothesized that bone marrow iron availability decreases due to decreased iron release by the mononuclear phagocyte system or that the anaemia in ACD is due to ineffective erythropoiesis; these remain controversial theories. Studies considering a decreased erythropoietin responsiveness have not produced consistent results. Erythroid colony growth is suppressed in vitro by interleukins and tumour necrosis factor but their role in vivo in ACD is unknown. The diagnosis of ACD is made by exclusion. Iron deficiency is detected by transferrin, ferritin, and cellular indices after adaptation of their normal values. Treatment of the anaemia consists merely of antirheumatic treatment. Iron administration is counterproductive since iron chelators or exogenous erythropoietin administration might increase erythropoiesis. |
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Authors:
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G Vreugdenhil; A J Swaak |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Rheumatology international Volume: 9 ISSN: 0172-8172 ISO Abbreviation: Rheumatol. Int. Publication Date: 1990 |
Date Detail:
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Created Date: 1990-04-17 Completed Date: 1990-04-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8206885 Medline TA: Rheumatol Int Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 243-57 Citation Subset: IM |
Affiliation:
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Zuiderziekenhuis, Department of Internal Medicine, Rotterdam, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Absorption Anemia / diagnosis, etiology*, therapy Arthritis, Rheumatoid / complications* Cell Survival Diagnosis, Differential Erythrocytes / physiology Erythropoiesis Erythropoietin / blood Ferritins / physiology Hemolysis Humans Iron / pharmacokinetics Lactoferrin / physiology Phagocytes / physiology Stem Cells / physiology |
| Chemical | |
Reg. No./Substance:
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0/Lactoferrin; 11096-26-7/Erythropoietin; 7439-89-6/Iron; 9007-73-2/Ferritins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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