Document Detail

Anaemia in rheumatoid arthritis: pathogenesis, diagnosis and treatment.
MedLine Citation:
PMID:  2180049     Owner:  NLM     Status:  MEDLINE    
The pathogenesis, diagnosis and treatment of the anaemia of chronic disorders (ACD) in rheumatoid arthritis (RA) were reviewed. Causes of anaemia other than ACD frequently present in RA. Decreased iron absorption was shown to be the result of active RA rather than a cause of ACD or iron deficiency. It has been hypothesized that bone marrow iron availability decreases due to decreased iron release by the mononuclear phagocyte system or that the anaemia in ACD is due to ineffective erythropoiesis; these remain controversial theories. Studies considering a decreased erythropoietin responsiveness have not produced consistent results. Erythroid colony growth is suppressed in vitro by interleukins and tumour necrosis factor but their role in vivo in ACD is unknown. The diagnosis of ACD is made by exclusion. Iron deficiency is detected by transferrin, ferritin, and cellular indices after adaptation of their normal values. Treatment of the anaemia consists merely of antirheumatic treatment. Iron administration is counterproductive since iron chelators or exogenous erythropoietin administration might increase erythropoiesis.
G Vreugdenhil; A J Swaak
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Rheumatology international     Volume:  9     ISSN:  0172-8172     ISO Abbreviation:  Rheumatol. Int.     Publication Date:  1990  
Date Detail:
Created Date:  1990-04-17     Completed Date:  1990-04-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8206885     Medline TA:  Rheumatol Int     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  243-57     Citation Subset:  IM    
Zuiderziekenhuis, Department of Internal Medicine, Rotterdam, The Netherlands.
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MeSH Terms
Anemia / diagnosis,  etiology*,  therapy
Arthritis, Rheumatoid / complications*
Cell Survival
Diagnosis, Differential
Erythrocytes / physiology
Erythropoietin / blood
Ferritins / physiology
Iron / pharmacokinetics
Lactoferrin / physiology
Phagocytes / physiology
Stem Cells / physiology
Reg. No./Substance:
0/Lactoferrin; 11096-26-7/Erythropoietin; 7439-89-6/Iron; 9007-73-2/Ferritins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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