Document Detail


Anaemia in myelofibrosis: its value in prognosis.
MedLine Citation:
PMID:  6849838     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Forty-four patients with myelofibrosis were investigated in our hospital in the period 1971-81. Their clinical, laboratory and radioisotope parameters were analysed. The direct correlation between plasma volume and splenic red cell pool has highlighted the role of the spleen in the dilutional anaemia seen in myelofibrosis. 52Fe quantitation enabled us to show that the bone marrow contributes relatively more to effective erythropoiesis than the extramedullary sites. The prognostic value of changes in plasma volume and bone marrow 52Fe activity has been demonstrated. We have shown that the Hb: reticulocyte relationship at diagnosis can be used to recognize probable stages of the disease and provides a useful prognostic determinant.
Authors:
O S Njoku; S M Lewis; D Catovsky; E C Gordon-Smith
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of haematology     Volume:  54     ISSN:  0007-1048     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  1983 May 
Date Detail:
Created Date:  1983-07-08     Completed Date:  1983-07-08     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  79-89     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Anemia / etiology*
Erythrocyte Count
Erythrocyte Indices
Erythropoiesis
Female
Hemoglobins / analysis
Humans
Male
Middle Aged
Plasma Volume
Primary Myelofibrosis / blood,  complications*,  mortality
Prognosis
Reticulocytes
Spleen / pathology
Chemical
Reg. No./Substance:
0/Hemoglobins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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