| Anaemia in myelofibrosis: its value in prognosis. | |
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MedLine Citation:
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PMID: 6849838 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Forty-four patients with myelofibrosis were investigated in our hospital in the period 1971-81. Their clinical, laboratory and radioisotope parameters were analysed. The direct correlation between plasma volume and splenic red cell pool has highlighted the role of the spleen in the dilutional anaemia seen in myelofibrosis. 52Fe quantitation enabled us to show that the bone marrow contributes relatively more to effective erythropoiesis than the extramedullary sites. The prognostic value of changes in plasma volume and bone marrow 52Fe activity has been demonstrated. We have shown that the Hb: reticulocyte relationship at diagnosis can be used to recognize probable stages of the disease and provides a useful prognostic determinant. |
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Authors:
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O S Njoku; S M Lewis; D Catovsky; E C Gordon-Smith |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: British journal of haematology Volume: 54 ISSN: 0007-1048 ISO Abbreviation: Br. J. Haematol. Publication Date: 1983 May |
Date Detail:
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Created Date: 1983-07-08 Completed Date: 1983-07-08 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0372544 Medline TA: Br J Haematol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 79-89 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Anemia / etiology* Erythrocyte Count Erythrocyte Indices Erythropoiesis Female Hemoglobins / analysis Humans Male Middle Aged Plasma Volume Primary Myelofibrosis / blood, complications*, mortality Prognosis Reticulocytes Spleen / pathology |
| Chemical | |
Reg. No./Substance:
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0/Hemoglobins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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