Document Detail

Anaemia of acute malaria infections in non-immune patients primarily results from destruction of uninfected erythrocytes.
MedLine Citation:
PMID:  10466119     Owner:  NLM     Status:  MEDLINE    
While anaemia has long been recognized as a consequence of acute infections with malaria, the relative contributions of direct erythrocyte destruction by parasites, destruction of uninfected erythrocytes and changes in erythropoiesis have been unclear. Fitting of parasitaemia and anaemia data from neurosyphilis patients undergoing malaria therapy to a mathematical model shows that in these patients, an average of 8.5 erythrocytes were destroyed in addition to each erythrocyte observed to become parasitized. The model also showed that dyserythropoiesis plays an insignificant role in the resulting anaemia. The anaemia occurs before a substantial antibody response to parasites or erythrocytes could be generated. We postulate that uninfected erythrocyte destruction occurs through phagocytosis of erythrocytes bound to merozoites killed as a result of the accompanying malaria paroxysms.
G N Jakeman; A Saul; W L Hogarth; W E Collins
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Parasitology     Volume:  119 ( Pt 2)     ISSN:  0031-1820     ISO Abbreviation:  Parasitology     Publication Date:  1999 Aug 
Date Detail:
Created Date:  1999-10-28     Completed Date:  1999-10-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401121     Medline TA:  Parasitology     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  127-33     Citation Subset:  IM    
School of Applied Mathematics and Statistics, Griffith University, Nathan, Queensland, Australia.
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MeSH Terms
Acute Disease
Anemia / etiology*
Computer Simulation
Erythrocytes / parasitology*
Malaria, Falciparum / blood*,  immunology*
Models, Theoretical
Neurosyphilis / therapy
Retrospective Studies

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