Document Detail

Anabolic steroids induce cardiac renin-angiotensin system and impair the beneficial effects of aerobic training in rats.
MedLine Citation:
PMID:  17906098     Owner:  NLM     Status:  MEDLINE    
We evaluated the effects of swimming and anabolic steroids (AS) on ventricular function, collagen synthesis, and the local renin-angiotensin system in rats. Male Wistar rats were randomized into control (C), steroid (S; nandrolone decanoate; 5 mg/kg sc, 2x/wk), steroid + losartan (SL; 20, trained (T), trained + steroid (T+S), and trained + steroid + losartan (T+SL; n = 14/group) groups. Swimming was performed 5 times/wk for 10 wk. Serum testosterone increased in S and T+S. Resting heart rate was lower in T and T+S. Percent change in left ventricular (LV) weight-to-body weight ratio increased in S, T, and T+S. LV systolic pressure declined in S and T+S. LV contractility increased in T (P < 0.05). LV relaxation increased in T (P < 0.05). It was significantly lower in T+S compared with C. Collagen volumetric fraction (CVF) and hydroxyproline were higher in S and T+S than in C and T (P < 0.05), and the CVF and LV hypertrophy were prevented by losartan treatment. LV-ANG I-converting enzyme activity increased (28%) in the S group (33%), and type III collagen synthesis increased (56%) in T+S but not in T group. A positive correlation existed between LV-ANG I-converting enzyme activity and collagen type III expression (r(2) = 0.88; P < 0.05, for all groups). The ANG II and angiotensin type 1a receptor expression increased in the S and T+S groups but not in T group. Supraphysiological doses of AS exacerbated the cardiac hypertrophy in exercise-trained rats. Exercise training associated with AS induces maladaptive remodeling and further deterioration in cardiac performance. Exercise training associated with AS causes loss of the beneficial effects in LV function induced by exercising. These results suggest that aerobic exercise plus AS increases cardiac collagen content associated with activation of the local renin-angiotensin system.
F L Rocha; E C Carmo; F R Roque; N Y Hashimoto; L V Rossoni; C Frimm; I Anéas; C E Negrão; J E Krieger; E M Oliveira
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-09-28
Journal Detail:
Title:  American journal of physiology. Heart and circulatory physiology     Volume:  293     ISSN:  0363-6135     ISO Abbreviation:  Am. J. Physiol. Heart Circ. Physiol.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-12-06     Completed Date:  2008-01-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901228     Medline TA:  Am J Physiol Heart Circ Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  H3575-83     Citation Subset:  IM    
Laboratory of Biochemistry, School of Physical Education and Sport, Avenida Prof. Mello Moraes 65, Butantã, Cidade Universitária, CEP 05508-9000 São Paulo, Brazil.
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MeSH Terms
Anabolic Agents / toxicity*
Angiotensin II / metabolism
Angiotensin II Type 1 Receptor Blockers / pharmacology
Blood Pressure / drug effects
Cardiomegaly / chemically induced*,  metabolism,  pathology,  physiopathology
Collagen / biosynthesis*,  genetics
Gene Expression Regulation / drug effects
Heart Rate / drug effects
Hydroxyproline / metabolism
Losartan / pharmacology
Myocardial Contraction / drug effects
Myocardium / metabolism*,  pathology
Nandrolone / analogs & derivatives*,  toxicity
Peptidyl-Dipeptidase A / metabolism
Rats, Wistar
Receptor, Angiotensin, Type 1 / metabolism
Renin-Angiotensin System / drug effects*
Testosterone / blood
Time Factors
Ventricular Function, Left / drug effects*
Ventricular Remodeling / drug effects
Reg. No./Substance:
0/Anabolic Agents; 0/Angiotensin II Type 1 Receptor Blockers; 0/Receptor, Angiotensin, Type 1; 11128-99-7/Angiotensin II; 114798-26-4/Losartan; 360-70-3/nandrolone decanoate; 434-22-0/Nandrolone; 51-35-4/Hydroxyproline; 58-22-0/Testosterone; 9007-34-5/Collagen; EC A

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