Document Detail

Anabolic steroids alter the haemodynamic effects of endurance training on the canine left ventricle.
MedLine Citation:
PMID:  3684514     Owner:  NLM     Status:  MEDLINE    
The effects of six week, high-dose anabolic steroid treatment (methandienone, 1.5 mg/kg/day) on the changes in left ventricular function induced in dogs by endurance training were studied by a catheterization technique under anaesthesia. Pacing, isoproterenol and dextran infusions were used as loading tests (respectively). Dogs were randomized into an exercise group (EG, n = 7) and an exercise-steroid group (ESG, n = 7), the latter receiving anabolic steroids as well as participating in the training program. In a standardized submaximal exercise test, the heart rate of unanesthetized dogs was lower both in the EG (p less than 0.001) and in the ESG (p less than 0.01) after the training period than before it. In the EG the resting systemic vascular resistance (SVR) before haemodynamic interventions was lower (p less than 0.05) and left ventricular stroke work (SW) was higher (p less than 0.05) after the training period than before. In the ESG, left ventricular ejection fraction (EF) decreased with training and anabolic steroid treatment (p less than 0.05). After the training period isoproterenol increased the maximum velocity of the cardiac contractile element significantly more (p less than 0.05) in the EG than in the ESG. Also SW increased in the EG (29%, p less than 0.001), but not in the ESG (-11%, NS). Endurance training increased the left ventricular end-diastolic and stroke volumes during isoproterenol infusion, but this training effect was attenuated by simultaneous anabolic steroid treatment (p less than 0.05 between the groups in both cases). During the isoproterenol test SVR decreased less in ESG than in EG (p less than 0.05 between).(ABSTRACT TRUNCATED AT 250 WORDS)
P Rämö; R Kettunen; J Timisjärvi; T Takala; L Hirvonen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pflügers Archiv : European journal of physiology     Volume:  410     ISSN:  0031-6768     ISO Abbreviation:  Pflugers Arch.     Publication Date:  1987 Oct 
Date Detail:
Created Date:  1988-01-12     Completed Date:  1988-01-12     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0154720     Medline TA:  Pflugers Arch     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  272-8     Citation Subset:  IM    
Department of Physiology, University of Oulu, Finland.
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MeSH Terms
Anabolic Agents / pharmacology*
Blood Pressure / drug effects
Heart Rate / drug effects
Hemodynamics / drug effects*
Isoproterenol / pharmacology
Methandrostenolone / pharmacology
Myocardial Contraction / drug effects
Physical Conditioning, Animal*
Physical Endurance / drug effects*
Physical Exertion
Stroke Volume / drug effects
Vascular Resistance / drug effects
Ventricular Function
Reg. No./Substance:
0/Anabolic Agents; 72-63-9/Methandrostenolone; 7683-59-2/Isoproterenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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