Document Detail

Anabolic steroid- and exercise-induced cardiac stress protein (HSP72) in the rat.
MedLine Citation:
PMID:  16862279     Owner:  NLM     Status:  MEDLINE    
The present study investigated the effects of exercise and anabolic-androgenic steroids on cardiac HSP72 expression. Male Wistar rats were divided into experimental groups: nandrolone exercise (NE, N = 6), control exercise (CE, N = 6), nandrolone sedentary (NS, N = 6), and control sedentary (CS, N = 6). Animals in the NE and NS groups received a weekly intramuscular injection (6.5 mg/kg of body weight) of nandrolone decanoate, while those in the CS and CE groups received mineral oil as vehicle. Animals in the NE and CE groups were submitted to a progressive running program on a treadmill, for 8 weeks. Fragments of the left ventricle were collected at sacrifice and the relative immunoblot contents of HSP72 were determined. Heart weight to body weight ratio was higher in exercised than in sedentary animals (P < 0.05, 4.65 +/- 0.38 vs 4.20 +/- 0.47 mg/g, respectively), independently of nandrolone, and in nandrolone-treated than untreated animals (P < 0.05, 4.68 +/- 0.47 vs 4.18 +/- 0.32 mg/g, respectively), independently of exercise. Cardiac HSP72 accumulation was higher in exercised than in sedentary animals (P < 0.05, 677.16 +/- 129.14 vs 246.24 +/- 46.30 relative unit, respectively), independently of nandrolone, but not different between nandrolone-treated and untreated animals (P > 0.05, 560.88 +/- 127.53 vs 362.52 +/- 95.97 relative unit, respectively) independently of exercise. Exercise-induced HSP72 expression was not affected by nandrolone. These levels of HSP72 expression in response to nandrolone administration suggest either a low intracellular stress or a possible less protection to the myocardium.
W Lunz; E C Oliveira; M T D Neves; E P B Fontes; C M G C Dias; A J Natali
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.]     Volume:  39     ISSN:  0100-879X     ISO Abbreviation:  Braz. J. Med. Biol. Res.     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-07-24     Completed Date:  2007-04-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8112917     Medline TA:  Braz J Med Biol Res     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  889-93     Citation Subset:  IM    
Departamento de Nutrição e Saúde, Universidade Federal de Viçosa, MG, Brasil.
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MeSH Terms
Anabolic Agents / pharmacology*
Blotting, Western
Body Weight
Electrophoresis, Polyacrylamide Gel
HSP72 Heat-Shock Proteins / analysis*,  drug effects
Heart Ventricles / drug effects,  metabolism
Myocardium / metabolism*
Nandrolone / analogs & derivatives*,  pharmacology
Organ Size
Physical Conditioning, Animal / physiology*
Rats, Wistar
Reg. No./Substance:
0/Anabolic Agents; 0/HSP72 Heat-Shock Proteins; 360-70-3/nandrolone decanoate; 434-22-0/Nandrolone

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