Document Detail


Anabolic steroid abuse and cardiac death.
MedLine Citation:
PMID:  8474379     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To examine the relationship between anabolic steroid abuse and cardiac death. We report the first two cases in Australia. They are the only reported cases in which the anabolic steroid oxymesterone has been detected. This compound has never been approved for use in Australia. CLINICAL FEATURES: Two footballers, aged 18 and 24, sustained fatal cardiac arrests while at training sessions. Both were considered fit and healthy. OUTCOME: Autopsy revealed features of a hypertrophic cardiomyopathy in the 18-year-old; the 24-year-old had findings of a myocarditis. In both cases the coronary arteries were normal and there was no evidence of coronary thrombosis. Urine in both subjects contained the anabolic steroid oxymesterone. CONCLUSIONS: There are limited clinical uses for anabolic steroids but they are widely abused by athletes in attempts to alter lean body mass and strength. Acute non-fatal myocardial infarction was first reported in 1988 and fatal myocardial infarction in 1990. While a causal relationship is hard to prove, it is possible that the anabolic steroid contributed to the increase in cardiac size in the first subject and may have increased his responsiveness to catecholamines causing an arrhythmogenic event. In the second, the inflammatory changes could have provided the focus for an arrhythmia. It would appear that anabolic steroid abuse should be considered in any athlete presenting with an acute vascular event.
Authors:
M C Kennedy; C Lawrence
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Medical journal of Australia     Volume:  158     ISSN:  0025-729X     ISO Abbreviation:  Med. J. Aust.     Publication Date:  1993 Mar 
Date Detail:
Created Date:  1993-05-18     Completed Date:  1993-05-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0400714     Medline TA:  Med J Aust     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  346-8     Citation Subset:  IM    
Affiliation:
Department of Clinical Pharmacology and Toxicology, St Vincent's Hospital, Darlinghurst, NSW.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Anabolic Agents*
Cardiomyopathy, Hypertrophic / chemically induced,  pathology
Death, Sudden, Cardiac / etiology*,  pathology
Doping in Sports
Football
Humans
Male
Myocarditis / chemically induced,  pathology
Substance-Related Disorders / complications*,  pathology
Chemical
Reg. No./Substance:
0/Anabolic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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