| Anabolic recovery relative to degree of prematurity after acute injury in neonates. | |
| | |
MedLine Citation:
|
PMID: 10022135 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: In contrast to full-term infants, premature neonates generate accelerated growth rates after birth in an attempt to "catch up" to normal weight-for-age levels. Because this catch-up ability is related to gestational age, the authors postulated that there would be significant differences in anabolic recovery based on the degree of prematurity. To evaluate this hypothesis in surgical and septic neonates, we used serial postoperative prealbumin (PA) serum concentrations as an index of the return to anabolic metabolism after surgical stress. METHODS: Serum PA concentrations were measured on the day of surgery (DOS) and daily for a 10-postoperative day (POD) period in 73 acutely ill neonates after surgery. These infants were divided into two groups: mature infants with gestational ages > or =35 weeks (average, 38.2+/-1.84; n = 55), and premature infants with gestational ages < or =34 weeks (average, 29.7+/-2.93; n = 18). Infants were subgrouped based on insult type into either surgery (n = 56), or sepsis (n = 17). Statistical significance between groups at the given postoperative times was established using independent unpaired t tests assuming unequal variances. RESULTS: There was no significant difference in the daily nitrogen and caloric intake between the groups. Although recovery of hepatic prealbumin synthesis after the resolution of injury insult increased progressively in both gestational age groups, premature infants increased prealbumin production significantly earlier and to a greater degree than their nearer-term counterparts. CONCLUSIONS: These results suggest an earlier return of anabolic protein metabolism after acute injury in premature neonates versus infants that are born nearer term in both the surgery and the sepsis subgroups. These findings may be useful in modifying strategies for protein and nutritional repletion in acutely stressed preterm infants. |
| | |
Authors:
|
J L Tueting; L O Byerley; W J Chwals |
Related Documents
:
|
15910445 - Identification of the motilin cells in duodenal epithelium of premature infants. 12660435 - Digoxin-like immunoreactive substance in nonoliguric hyperkalemia of the premature infant. 15121985 - Exposure to di-(2-ethylhexyl) phthalate among premature neonates in a neonatal intensiv... 19745085 - Cerebellum of the premature infant: rapidly developing, vulnerable, clinically important. 9177975 - A critical appraisal of current management practices for infant regurgitation--recommen... 13679935 - Postnatal malnutrition of extremely low birth-weight infants with catch-up growth postd... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Journal of pediatric surgery Volume: 34 ISSN: 0022-3468 ISO Abbreviation: J. Pediatr. Surg. Publication Date: 1999 Jan |
Date Detail:
|
Created Date: 1999-04-13 Completed Date: 1999-04-13 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 0052631 Medline TA: J Pediatr Surg Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 13-6; discussion 16-7 Citation Subset: IM |
Affiliation:
|
University of Chicago Pritzker School of Medicine, Department of Surgery, IL 60637, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Energy Metabolism* Humans Infant, Newborn Infant, Premature / physiology* Liver / metabolism Postoperative Period Sepsis / metabolism* Stress, Physiological / metabolism* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Characteristics of protein and energy metabolism in neonates with necrotizing enterocolitis--a pilot...
Next Document: Glucagonlike peptide-2 enhances small intestinal absorptive function and mucosal mass in vivo.