| Anabolic androgenic steroid nandrolone decanoate reduces hypothalamic proopiomelanocortin mRNA levels. | |
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MedLine Citation:
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PMID: 12965238 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Supratherapeutical doses of anabolic androgenic steroids (AASs) have dramatic effects on metabolism in humans, and also inhibit feeding and reduce the rate of body weight gain in rats. In order to test the hypothesis that the AAS metabolic syndrome is accompanied by alterations in the central melanocortin system, we evaluated body weight, food intake and hypothalamic agouti-related protein (AgRP) and proopiomelanocortin (POMC) mRNA levels following administration of different doses of the anabolic androgenic steroid nandrolone decanoate. In order to distinguish changes induced by the steroid treatment per se from those resulting from the reduced food intake and growth rate, we also compared the effect of nandrolone decanoate on AgRP and POMC mRNA expression with both normally fed, and food restricted control groups. We here report that administration of nandrolone specifically reduces arcuate nucleus POMC mRNA levels while not affecting the expression level of AgRP. The effect on POMC expression was not observed in the food restricted controls, excluding the possibility that the observed effect was a mere response to the reduced food intake and body weight. These results raise the possibility that some of the metabolic and behavioural consequences of AAS abuse may be the result of alterations in the melanocortin system. |
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Authors:
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Jonas Lindblom; Anna M S Kindlundh; Fred Nyberg; Lena Bergström; Jarl E S Wikberg |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Brain research Volume: 986 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 2003 Oct |
Date Detail:
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Created Date: 2003-09-10 Completed Date: 2003-12-15 Revised Date: 2011-08-03 |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 139-47 Citation Subset: IM |
Affiliation:
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Department of Neuroscience, Division of Pharmacology, Uppsala University, Box 591 BMC, S-751 24 Uppsala, Sweden. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Agouti-Related Protein Animals Arcuate Nucleus / drug effects, metabolism Body Weight / drug effects, physiology Dose-Response Relationship, Drug Down-Regulation / drug effects*, physiology Drinking / drug effects, physiology Eating / drug effects, physiology Food Deprivation / physiology Hypothalamus / drug effects*, metabolism Intercellular Signaling Peptides and Proteins Male Nandrolone / analogs & derivatives*, pharmacology* Pro-Opiomelanocortin / genetics* Proteins / genetics* RNA, Messenger / drug effects, metabolism Rats Rats, Sprague-Dawley alpha-MSH / metabolism |
| Chemical | |
Reg. No./Substance:
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0/AGRP protein, rat; 0/Agouti-Related Protein; 0/Intercellular Signaling Peptides and Proteins; 0/Proteins; 0/RNA, Messenger; 360-70-3/nandrolone decanoate; 434-22-0/Nandrolone; 581-05-5/alpha-MSH; 66796-54-1/Pro-Opiomelanocortin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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