| Anabolic androgenic steroid abuse: multiple mechanisms of regulation of GABAergic synapses in neuroendocrine control regions of the rodent forebrain. | |
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MedLine Citation:
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PMID: 21554430 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Anabolic androgenic steroids (AAS) are synthetic derivatives of testosterone originally developed for clinical purposes but are now predominantly taken at suprapharmacological levels as drugs of abuse. To date, almost 100 different AAS compounds that vary in metabolic fate and physiological effects have been designed and synthesised. Although they are administered for their ability to enhance muscle mass and performance, untoward side effects of AAS use include changes in reproductive and sexual behaviours. Specifically, AAS, depending on the type of compound administered, can delay or advance pubertal onset, lead to irregular oestrous cyclicity, diminish male and female sexual behaviours, and accelerate reproductive senescence. Numerous brains regions and neurotransmitter signalling systems are involved in the generation of these behaviours, and are potential targets for both chronic and acute actions of the AAS. However, critical to all of these behaviours is neurotransmission mediated by GABA(A) receptors within a nexus of interconnected forebrain regions that includes the medial preoptic area, the anteroventral periventricular nucleus and the arcuate nucleus of the hypothalamus. We review how exposure to AAS alters GABAergic transmission and neural activity within these forebrain regions, taking advantage of in vitro systems and both wild-type and genetically altered mouse strains, aiming to better understand how these synthetic steroids affect the neural systems that underlie the regulation of reproduction and the expression of sexual behaviours. |
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Authors:
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J G Oberlander; D M Porter; C A A Penatti; L P Henderson |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review |
Journal Detail:
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Title: Journal of neuroendocrinology Volume: 24 ISSN: 1365-2826 ISO Abbreviation: J. Neuroendocrinol. Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2011-12-22 Completed Date: 2012-06-01 Revised Date: 2013-02-20 |
Medline Journal Info:
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Nlm Unique ID: 8913461 Medline TA: J Neuroendocrinol Country: England |
Other Details:
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Languages: eng Pagination: 202-14 Citation Subset: IM |
Copyright Information:
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© 2011 The Authors. Journal of Neuroendocrinology © 2011 Blackwell Publishing Ltd. |
Affiliation:
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Department of Physiology and Neurobiology, Dartmouth Medical School, Hanover, NH 03755, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anabolic Agents
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pharmacology* Androgens / pharmacology* Animals Mice Neurons / drug effects, metabolism Prosencephalon / drug effects*, metabolism Synapses / drug effects*, metabolism Synaptic Transmission / drug effects, physiology gamma-Aminobutyric Acid / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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R01 DA014137-18/DA/NIDA NIH HHS; R01 DA018255-05/DA/NIDA NIH HHS; R01-DA14137/DA/NIDA NIH HHS; R01-DA18255/DA/NIDA NIH HHS; T32 DK007508-25/DK/NIDDK NIH HHS; T32-DK07508/DK/NIDDK NIH HHS; U54 HD28934/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anabolic Agents; 0/Androgens; 56-12-2/gamma-Aminobutyric Acid |
| Comments/Corrections | |
Erratum In:
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J Neuroendocrinol. 2012 May;24(5):849 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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