Document Detail


Anabolic androgenic steroid abuse: multiple mechanisms of regulation of GABAergic synapses in neuroendocrine control regions of the rodent forebrain.
MedLine Citation:
PMID:  21554430     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Anabolic androgenic steroids (AAS) are synthetic derivatives of testosterone originally developed for clinical purposes but are now predominantly taken at suprapharmacological levels as drugs of abuse. To date, almost 100 different AAS compounds that vary in metabolic fate and physiological effects have been designed and synthesised. Although they are administered for their ability to enhance muscle mass and performance, untoward side effects of AAS use include changes in reproductive and sexual behaviours. Specifically, AAS, depending on the type of compound administered, can delay or advance pubertal onset, lead to irregular oestrous cyclicity, diminish male and female sexual behaviours, and accelerate reproductive senescence. Numerous brains regions and neurotransmitter signalling systems are involved in the generation of these behaviours, and are potential targets for both chronic and acute actions of the AAS. However, critical to all of these behaviours is neurotransmission mediated by GABA(A) receptors within a nexus of interconnected forebrain regions that includes the medial preoptic area, the anteroventral periventricular nucleus and the arcuate nucleus of the hypothalamus. We review how exposure to AAS alters GABAergic transmission and neural activity within these forebrain regions, taking advantage of in vitro systems and both wild-type and genetically altered mouse strains, aiming to better understand how these synthetic steroids affect the neural systems that underlie the regulation of reproduction and the expression of sexual behaviours.
Authors:
J G Oberlander; D M Porter; C A A Penatti; L P Henderson
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Journal of neuroendocrinology     Volume:  24     ISSN:  1365-2826     ISO Abbreviation:  J. Neuroendocrinol.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2011-12-22     Completed Date:  2012-06-01     Revised Date:  2014-08-15    
Medline Journal Info:
Nlm Unique ID:  8913461     Medline TA:  J Neuroendocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  202-14     Citation Subset:  IM    
Copyright Information:
© 2011 The Authors. Journal of Neuroendocrinology © 2011 Blackwell Publishing Ltd.
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MeSH Terms
Descriptor/Qualifier:
Anabolic Agents / pharmacology*
Androgens / pharmacology*
Animals
Mice
Neurons / drug effects,  metabolism
Prosencephalon / drug effects*,  metabolism
Synapses / drug effects*,  metabolism
Synaptic Transmission / drug effects,  physiology
gamma-Aminobutyric Acid / metabolism*
Grant Support
ID/Acronym/Agency:
R01 DA014137-18/DA/NIDA NIH HHS; R01 DA018255-05/DA/NIDA NIH HHS; R01-DA14137/DA/NIDA NIH HHS; R01-DA18255/DA/NIDA NIH HHS; T32 DK007508-25/DK/NIDDK NIH HHS; T32-DK07508/DK/NIDDK NIH HHS; U54 HD28934/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Anabolic Agents; 0/Androgens; 56-12-2/gamma-Aminobutyric Acid
Comments/Corrections
Erratum In:
J Neuroendocrinol. 2012 May;24(5):849

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