Document Detail


The anabolic response to resistance exercise and a protein-rich meal is not diminished by age.
MedLine Citation:
PMID:  21528164     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: The synergistic effect of resistance exercise and protein ingestion on muscle protein anabolism in young adults has been well described. However, it is unclear if this relationship is maintained in older adults who are at greater risk of sarcopenic muscle loss. To this end, we sought to determine if the synergistic response to a bout of resistance exercise and a protein-rich lean beef meal was altered by age.
SETTING: The University of Texas Medical Branch, Clinical Research Center, Galveston, Texas.
PARTICIPANTS: Healthy young (n=7, 29±3 y) and older (n=7, 67±2 y) adults.
DESIGN: Mixed muscle fractional synthesis rate (FSR) was calculated during a 3 h post-absorptive/rest period and again during a 5 h period following ingestion of a protein-rich meal (340 g lean beef) and bout of resistance exercise (6 sets of 8 repetitions of isotonic knee extension exercise at 80% one repetition maximum).
MEASUREMENTS: Venous blood samples and vastus lateralis muscle biopsy samples were obtained during a primed (2.0 µmol/kg) constant infusion (0.08 µmol∙kg(-1)min(-1)) of L- [ring-13C6] phenylalanine.
RESULTS: Mixed muscle FSR increased by approximately 108% in both young [pre: 0.073±0.008; post: 0.156±0.021(SE) %/h, p<0.001] and older adults (pre: 0.075±0.004; post: 0.152±0.017 %/h, p=0.003) following the meal and resistance exercise bout.
CONCLUSION: Aging does not diminish the increase in muscle protein synthesis following a high-quality protein rich meal and bout of resistance exercise.
Authors:
T B Symons; M Sheffield-Moore; M M Mamerow; R R Wolfe; D Paddon-Jones
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The journal of nutrition, health & aging     Volume:  15     ISSN:  1760-4788     ISO Abbreviation:  J Nutr Health Aging     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-29     Completed Date:  2011-11-09     Revised Date:  2013-07-09    
Medline Journal Info:
Nlm Unique ID:  100893366     Medline TA:  J Nutr Health Aging     Country:  France    
Other Details:
Languages:  eng     Pagination:  376-81     Citation Subset:  IM    
Affiliation:
Division of Rehabilitation Sciences, The University of Texas Medical Branch, Galveston, Texas 77555-1144, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aging / physiology*
Biopsy
Dietary Proteins / pharmacology*
Exercise / physiology*
Female
Humans
Male
Meat
Muscle Proteins / biosynthesis*
Phenylalanine / metabolism
Quadriceps Muscle / metabolism*,  physiology
Resistance Training*
Grant Support
ID/Acronym/Agency:
1UL1RR029876-01/RR/NCRR NIH HHS; M01 RR-00073/RR/NCRR NIH HHS; P30 AG17231/AG/NIA NIH HHS; UL1 RR029876/RR/NCRR NIH HHS; UL1 RR029876-01/RR/NCRR NIH HHS; UL1 TR000071/TR/NCATS NIH HHS
Chemical
Reg. No./Substance:
0/Dietary Proteins; 0/Muscle Proteins; 63-91-2/Phenylalanine
Comments/Corrections

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