| Anabaena sensory rhodopsin is a light-driven unidirectional rotor. | |
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MedLine Citation:
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PMID: 21098308 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The implementation of multiconfigurational quantum chemistry methods into a quantum-mechanics/molecular-mechanics protocol has allowed the construction of a realistic computer model for the sensory rhodopsin of the cyanobacterium Anabaena PCC 7120. The model, which reproduces the absorption spectra of both the all-trans and 13-cis forms of the protein and their associated K and L intermediates, is employed to investigate the light-driven steps of the photochromic cycle exhibited by the protein. It is found that the photoisomerizations of the all-trans and 13-cis retinal chromophores occur through unidirectional, counterclockwise 180° rotations of the =C14-C15= moiety with respect to the Lys210-linked end of the chromophore axis. Thus, the sequential interconversions of the all-trans and 13-cis forms during a single photochromic cycle yield a complete (360°) unidirectional rotation of the =C14-C15= moiety. This finding implies that Anabaena sensory rhodopsin is a biological realization of a light-driven molecular rotor. |
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Authors:
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Angela Strambi; Bo Durbeej; Nicolas Ferré; Massimo Olivucci |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-11-22 |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 107 ISSN: 1091-6490 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2011-03-22 Completed Date: 2011-05-12 Revised Date: 2011-08-01 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: United States |
Other Details:
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Languages: eng Pagination: 21322-6 Citation Subset: IM |
Affiliation:
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Dipartimento di Chimica, Università di Siena, Siena I-53100, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anabaena
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chemistry* Computer Simulation Light* Models, Molecular Molecular Motor Proteins / chemistry*, metabolism* Molecular Structure Quantum Theory Sensory Rhodopsins / chemistry*, metabolism* Static Electricity |
| Chemical | |
Reg. No./Substance:
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0/Molecular Motor Proteins; 0/Sensory Rhodopsins |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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