Document Detail

Amyotrophic lateral sclerosis mortality in Italy, 1958 to 1987: a cross-sectional and cohort study.
MedLine Citation:
PMID:  8492947     Owner:  NLM     Status:  MEDLINE    
We analyzed the mortality rates of amyotrophic lateral sclerosis (ALS) in Italy from 1958 to 1987. The overall mean annual mortality rate, adjusted to the 1981 Italian population, was 0.68/100,000 (95% confidence interval, 0.64 to 0.72); 0.86 for men; and 0.62 for women. During that period, mortality increased for both sexes: from 1958/1962 to 1983/1987, mortality increased by 60% for women and 24% for men. The slope for women was 0.07, and for men, 0.02. Moreover, the mortality rate increased in older age groups and was stable for subjects under 45 years old. There was no clear birth-cohort effect, but in any cohort the age-specific mortality rate increased with advancing age, with no decline for the oldest age. Based on these data, the increase of ALS mortality rates is probably due to the effect of changing methodologic and demographic variables and the decrease of mortality of some competing diseases, rather than a real rise of the risk in the whole population or in specific birth cohorts.
A Chiò; C Magnani; D Schiffer
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurology     Volume:  43     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  1993 May 
Date Detail:
Created Date:  1993-06-11     Completed Date:  1993-06-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  927-30     Citation Subset:  AIM; IM    
Second Department of Neurology, University of Turin, Italy.
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MeSH Terms
Age Factors
Aged, 80 and over
Amyotrophic Lateral Sclerosis / epidemiology,  mortality*
Cohort Studies
Cross-Sectional Studies
Italy / epidemiology
Middle Aged
Sex Factors
Time Factors

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