Document Detail

Amyotrophic lateral sclerosis associated with pregnancy: report of four new cases and review of the literature.
MedLine Citation:
PMID:  12745618     Owner:  NLM     Status:  MEDLINE    
Pregnancy in women with ALS is rare and is generally considered a potentially dangerous event. We describe four ALS cases associated with pregnancy, together with a review of the literature. Three of the four women described developed ALS during pregnancy. In three cases a normal delivery was performed, with a healthy child. One patient, with severe respiratory failure, underwent an interruption of pregnancy. Seven other cases are reported in the literature, featuring a total of 11 pregnancies. The association between pregnancy and ALS is quite rare, and a pathogenic relationship cannot be excluded. The pregnancy and the delivery may be normal, but respiratory function should be carefully monitored. Generally, ALS does not have deleterious effects on fetal development. However, pregnancy in a woman with severe respiratory failure may precipitate the disease.
Adriano Chiò; Andrea Calvo; Nicoletta Di Vito; Marco Vercellino; Paolo Ghiglione; Anna Terreni; Roberto Mutani; Gabriele Mora
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases     Volume:  4     ISSN:  1466-0822     ISO Abbreviation:  Amyotroph. Lateral Scler. Other Motor Neuron Disord.     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-05-14     Completed Date:  2003-08-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  100964775     Medline TA:  Amyotroph Lateral Scler Other Motor Neuron Disord     Country:  England    
Other Details:
Languages:  eng     Pagination:  45-8     Citation Subset:  IM    
Second Division of Neurology, Department of Neurosciences, University of Torino, Turin, Italy.
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MeSH Terms
Abortion, Induced
Amyotrophic Lateral Sclerosis / complications*,  diagnosis*,  therapy
Pregnancy Complications / diagnosis*,  etiology,  surgery
Respiratory Insufficiency / etiology*

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