Document Detail


Amyotrophic lateral sclerosis: amino acid levels in plasma and cerebrospinal fluid.
MedLine Citation:
PMID:  2375629     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Concentrations of glutamic acid have been reported to be elevated in fasting plasma and cerebrospinal fluid (CSF) of patients with amyotrophic lateral sclerosis (ALS); glycine concentrations have also been reported to be increased in the CSF of such patients. Autopsy studies have shown glutamate contents to be significantly decreased in brain and spinal cord in ALS. These observations suggested that a systemic abnormality of glutamate metabolism might underlie the pathogenesis of ALS. We report here the findings of our studies of amino acid concentrations in patients with the sporadic form of ALS. Glutamate concentrations were normal in the fasting plasma of a great majority of the patients with ALS. Concentrations of glutamate, aspartate, and glycine were normal in the CSF of all 17 patients examined. beta-N-Methylamino-L-alanine, a plant neurotoxin possibly responsible for causing the Guamanian form of ALS, was not detectable in the plasma or CSF of any of our patients. Our findings do not lend support to the hypothesis that the sporadic form of ALS results from overexcitation of motor neurons by excitatory amino acids.
Authors:
T L Perry; C Krieger; S Hansen; A Eisen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of neurology     Volume:  28     ISSN:  0364-5134     ISO Abbreviation:  Ann. Neurol.     Publication Date:  1990 Jul 
Date Detail:
Created Date:  1990-08-24     Completed Date:  1990-08-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7707449     Medline TA:  Ann Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  12-7     Citation Subset:  IM    
Affiliation:
Department of Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Amino Acids / blood,  cerebrospinal fluid,  metabolism
Amyotrophic Lateral Sclerosis / blood*,  cerebrospinal fluid,  metabolism
Female
Glutamates / blood*,  cerebrospinal fluid,  metabolism
Glycine / blood,  cerebrospinal fluid,  metabolism
Humans
Male
Middle Aged
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Glutamates; 56-40-6/Glycine
Comments/Corrections
Comment In:
Ann Neurol. 1992 Apr;31(4):449-50   [PMID:  1586146 ]
Ann Neurol. 1991 Jan;29(1):110   [PMID:  1996873 ]
Ann Neurol. 1990 Jul;28(1):9-11   [PMID:  2375640 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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