Document Detail

Amyopathic dermatomyositis: retrospective review of 37 cases.
MedLine Citation:
PMID:  11907509     Owner:  NLM     Status:  MEDLINE    
Criteria for diagnosis of amyopathic dermatomyositis vary, and the prognosis is not clear. Our purpose was to investigate prognosis regarding progression to myositis and associated malignancy. We reviewed the medical records of patients with dermatomyositis evaluated at our institution from 1976 to 1994. Of 746 patients with dermatomyositis, 37 (5%) with the amyopathic subtype were divided into 3 groups: group 1 (73%), no subjective or objective evidence of myopathy; group 2 (13%), no subjective muscle weakness but abnormalities detected by objective tests; group 3 (13%), subjective muscle weakness but no objective evidence of myopathy. Follow-up was conducted by means of a mailed questionnaire. For 25 patients, follow-up of 1 to 17 years after diagnosis showed muscle weakness in 2 patients in group 1 within 5 years after diagnosis. Five patients (13%) had associated malignancies. Of 7 (19%) patients with disease onset before the age of 18 years, none had progression to myopathy. Although it presents with cutaneous lesions indistinguishable from those of classic dermatomyositis, amyopathic dermatomyositis is a distinct entity. In most patients, amyopathic dermatomyositis does not progress to myopathy. Prognosis appears favorable, but malignancy may develop.
Rokea A el-Azhary; Soheil Y Pakzad
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the American Academy of Dermatology     Volume:  46     ISSN:  0190-9622     ISO Abbreviation:  J. Am. Acad. Dermatol.     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-03-21     Completed Date:  2002-05-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7907132     Medline TA:  J Am Acad Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  560-5     Citation Subset:  IM    
Department of Dermatology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
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MeSH Terms
Age of Onset
Aged, 80 and over
Child, Preschool
Dermatomyositis / classification,  diagnosis*,  pathology
Follow-Up Studies
Middle Aged
Muscle, Skeletal / pathology
Paraneoplastic Syndromes / pathology
Retrospective Studies
Skin / pathology

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