| Amyloidosis of the small intestine. | |
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MedLine Citation:
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PMID: 17344006 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Amyloidosis is a rare disease characterized by forming pathological protein deposits - amyloid - in many organs and tissues. This decreases their functionality. The aim of this small study was to determine, whether the radiological picture of the small intestine involvement in amyloidosis is in some sense specific as sometimes described in literature giving rise to high suspicion for the disease in symptomatic patients. MATERIAL AND METHODS: The prospective study comprising seven patients hospitalized in surgical department is presented together with a survey on the disease, its appearance in radiological imaging. All patients underwent abdominal ultrasound (ATL 5000 HDI, 7-12MHz linear probe, no contrast enhancement, supine position), abdominal CT (Somatom Plus, Siemens, single detector, conventional abdominal CT protocol) and enteroclysis (Micropaque suspension 300ml, application rate of 75ml/min, dilution with HP-7000 being 1:1 and HP-7000 solution 2000ml, application rate of 120ml/min.). RESULTS: The amyloid deposits in the small intestine could be visualized in five of seven patients with the disease. Enteroclysis revealed a diffuse slowed down intestinal motility with an obstruction-like picture in all of our seven patients. The intestinal secretion was normal, plicae were getting polyp-like shape in five of them forming so called "thumb printing" picture. CT showed thickening of the intestinal wall due to deposits with poor blood supply and contrast retention in five of seven patients. Ultrasound visualized thickened, hypoechoic nodular plicae and slowed down motility in these five patients. The most striking finding was the pathological deposits in the intestinal wall were highly hypo-vascular. However, this picture is very similar to that of ischemic enteritis. All seven patients had proven amyloid deposits from bioptic specimens. CONCLUSION: The diagnosis of amyloidosis must be supported by bioptic examination as it has no pathognomic radiological picture. Nevertheless, it allows usually to rise a high suspicion for this and sometimes even guess the type of the pathological protein involved. This can start a search for the primary reason of possible amyloidosis and thus perhaps spear the patients quality of life. |
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Authors:
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Zdenek Kala; Vlastimil Válek; Petr Kysela |
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Publication Detail:
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Type: Evaluation Studies; Journal Article Date: 2007-03-06 |
Journal Detail:
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Title: European journal of radiology Volume: 63 ISSN: 0720-048X ISO Abbreviation: Eur J Radiol Publication Date: 2007 Jul |
Date Detail:
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Created Date: 2007-06-19 Completed Date: 2007-12-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8106411 Medline TA: Eur J Radiol Country: Ireland |
Other Details:
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Languages: eng Pagination: 105-9 Citation Subset: IM |
Affiliation:
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Department of Surgery, Faculty Hospital Brno, Jihlavska 20, 62500 Brno, Czech Republic. zkala@tiscali.cz |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amyloidosis
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complications,
diagnosis* Barium Sulfate / diagnostic use Contrast Media / administration & dosage Dyspepsia / etiology Humans Image Enhancement / methods Intestinal Diseases / diagnosis* Intestine, Small / radiography*, ultrasonography Intubation, Gastrointestinal / methods Prospective Studies Rare Diseases Sensitivity and Specificity Tomography, X-Ray Computed |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 7727-43-7/Barium Sulfate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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