Document Detail

Amyloidosis of a possible new type in patients receiving long-term hemodialysis.
MedLine Citation:
PMID:  2413819     Owner:  NLM     Status:  MEDLINE    
Carpal tunnel syndrome developed in six patients receiving long-term (12 to 17 years) hemodialysis. Biopsy specimens of tendons and synovial-tendon sheaths showed deposition of eosinophilic hyalin material exhibiting many properties of amyloid. However, this material did not react with antibodies to known amyloid proteins, except for the P component. On electron microscopy, the material consisted of fine filaments, 9 to 10 nm thick, that showed a marked tendency to parallel alignment and arrangement in bundles. The same material was found in arterioles of the rectum in three of four patients who were examined. We suggest that this material represents a previously undescribed type of amyloid. Its deposition may be due to the effects of long-term hemodialysis, or to the long-term uremic state, and may pose a potential problem to dialyzed patients.
T Morita; M Suzuki; A Kamimura; Y Hirasawa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of pathology & laboratory medicine     Volume:  109     ISSN:  0003-9985     ISO Abbreviation:  Arch. Pathol. Lab. Med.     Publication Date:  1985 Nov 
Date Detail:
Created Date:  1985-11-19     Completed Date:  1985-11-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7607091     Medline TA:  Arch Pathol Lab Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1029-32     Citation Subset:  AIM; IM    
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MeSH Terms
Amyloidosis / etiology*,  metabolism,  pathology
Arterioles / metabolism,  pathology
Carpal Tunnel Syndrome / etiology*,  metabolism,  pathology
Hyalin / metabolism
Middle Aged
Rectum / blood supply
Renal Dialysis / adverse effects*
Synovial Membrane / metabolism,  pathology
Tendons / metabolism,  pathology
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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