| Amyloidosis is frequently undetected in patients with rheumatoid arthritis. | |
| | |
MedLine Citation:
|
PMID: 19065298 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Prevalence of AA amyloid in rheumatoid arthritis (RA) is still unclear. The objective of this retrospective study was whether dedicated re-examination of autopsy tissues from RA patients increases the detection rate of amyloid compared to routine examination. Amyloid was re-examined in tissue samples and detection rate compared with original reports of 369 consecutively autopsied RA patients and 370 non-RA patients matched for sex, age, and year of autopsy between 1952 and 1991. Re-examination of 90% of the 739 cases showed doubling of the prevalence of amyloid compared with the original reports: from 18 to 30% in RA and from 2 to 4% in non-RA patients. In RA patients, cardiac amyloid was as frequent as renal amyloid. In RA patients with amyloid at re-examination, amyloidosis had been diagnosed before autopsy in 37%, and these patients had more inflammation and longer disease duration than RA patients without amyloid. Only 56% of RA patients with renal amyloid were known to have proteinuria. In conclusion, this autopsy study shows that amyloid in RA is a common finding which remains frequently undetected. In patients with active and long-lasting RA, a systematic search for amyloid may enable early diagnosis of amyloidosis, which will require effective suppression of inflammation. |
| | |
Authors:
|
Riitta Koivuniemi; Leena Paimela; Risto Suomalainen; Tom Tornroth; Marjatta Leirisalo-Repo |
Related Documents
:
|
6618778 - On understanding and not understanding: some technical issues. 15769568 - Evidence-based treatment of psychiatric patient. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis Volume: 15 ISSN: 1744-2818 ISO Abbreviation: Amyloid Publication Date: 2008 Dec |
Date Detail:
|
Created Date: 2008-12-09 Completed Date: 2009-01-28 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9433802 Medline TA: Amyloid Country: United States |
Other Details:
|
Languages: eng Pagination: 262-8 Citation Subset: IM |
Affiliation:
|
Division of Rheumatology, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland. riitta.koivuniemi@hus.fi |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Amyloidosis / complications*, diagnosis*, metabolism, mortality Arthritis, Rheumatoid / complications*, metabolism, mortality Autopsy Cause of Death Female Finland / epidemiology Humans Male Middle Aged Retrospective Studies Serum Amyloid A Protein / metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Serum Amyloid A Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Serum transthyretin levels in senile systemic amyloidosis: effects of age, gender and ethnicity.
Next Document: Finding of vascular amyloid TTR in inferior nasal concha in a patient with FAP TTRVal30Met.