| Amyloid precursor protein accumulates in white matter at the margin of a focal ischaemic lesion. | |
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MedLine Citation:
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PMID: 9237529 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Amyloid precursor protein (APP) is transported by fast anterograde axonal transport. Since disruption of this transport results in APP accumulation, APP has been proposed as a sensitive marker of axonal injury. In the present study, axonal injury in subcortical white matter and myelinated fibre tracts permeating the striatum, 24 h after permanent middle cerebral artery occlusion in the rat, has been examined by assessing the location and extent of APP immunoreactivity. Increased APP immunoreactivity was present in both areas. This was localised to a circumscribed zone immediately adjacent to the boundary of the ischaemic lesion in grey matter. The amount of APP immunoreactivity was associated with the volume of the ischaemic lesion in individual animals. Increased APP immunoreactivity in subcortical white matter and myelinated fibre tracts at the margin of the ischaemic zone may prove to be a valuable marker for assessing strategies to protect axons after an ischaemic insult. |
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Authors:
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P S Yam; T Takasago; D Dewar; D I Graham; J McCulloch |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Brain research Volume: 760 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 1997 Jun |
Date Detail:
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Created Date: 1997-10-28 Completed Date: 1997-10-28 Revised Date: 2009-09-29 |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 150-7 Citation Subset: IM |
Affiliation:
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Wellcome Surgical Institute and Hugh Fraser Neuroscience Laboratories, University of Glasgow, Garscube Estate, UK. 9407845y@udcf.gla.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amyloid beta-Protein Precursor
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metabolism* Animals Brain Ischemia / metabolism* Disease Models, Animal Immunohistochemistry Male Rats Rats, Inbred F344 |
| Grant Support | |
ID/Acronym/Agency:
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//Wellcome Trust |
| Chemical | |
Reg. No./Substance:
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0/Amyloid beta-Protein Precursor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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