| Amyloid neuropathy mimicking chronic inflammatory demyelinating polyneuropathy. | |
| | |
MedLine Citation:
|
PMID: 22190302 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Introduction: Amyloid neuropathy is a rare peripheral neuropathy that classically presents as a progressive sensory neuropathy with prominent autonomic involvement. Methods: We describe 5 patients with amyloid neuropathy (familial amyloid polyneuropathy or acquired amyloidosis) who were initially mistaken to have chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) based on history, clinical examination, electrodiagnostic studies, and cerebrospinal fluid (CSF) analysis. Results: The diagnosis of CIDP had been retained on clinical and electrophysiological grounds for all patients, but we observed no improvement after immunomodulatory treatment. Nerve biopsy confirmed amyloid deposits in nerves, and molecular genetic analysis showed a mutation of the transthyretin (V30M) gene for 3 patients; the 2 other patients had acquired amyloidosis. Conclusions: This report emphasizes the need to look for an alternative diagnosis in CIDP patients who do not respond to treatment and to look carefully for symptoms or signs of autonomic involvement in such patients. Muscle Nerve 45: 26-31, 2012. |
| | |
Authors:
|
Stephane Mathis; Laurent Magy; Laho Diallo; Sami Boukhris; Jean-Michel Vallat |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Muscle & nerve Volume: 45 ISSN: 1097-4598 ISO Abbreviation: Muscle Nerve Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2011-12-22 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7803146 Medline TA: Muscle Nerve Country: United States |
Other Details:
|
Languages: eng Pagination: 26-31 Citation Subset: IM |
Copyright Information:
|
Copyright © 2011 Wiley Periodicals, Inc. |
Affiliation:
|
Department of Neurology, CHU Poitiers, University of Poitiers, Poitiers, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Interobserver agreement of Medical Research Council sum-score and handgrip strength in the intensive...
Next Document: Protective effect of sodium ascorbate on efficacy of intramuscular transplantation of autologous mus...