Document Detail


Amyloid imaging mismatch.
MedLine Citation:
PMID:  22785519     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
ABSTRACT: An 82-year-old man with suspected systemic amyloidosis and complete atrioventricular block underwent vascular biopsy during his pacemaker implantation with pathology showing amyloid deposits. Tc-aprotinin SPECT revealed increased radiotracer uptake along the left ventricular wall, consistent with cardiac amyloidosis. C-PiB PET/CT performed for the evaluation of amyloid deposits in the brain showed findings suggestive of Alzheimer disease without abnormal radiotracer concentration in the myocardium to match the Tc-aprotinin SPECT findings. Dynamic PET images showed increased C-PiB concentration in the left ventricular myocardium at 2 minutes after injection, with subsequent tracer clearance by approximately 5 minutes, consistent with normal C-PiB biodistribution.
Authors:
Ryogo Minamimoto; Kenji Ishii; Kazuo Kubota; Miyako Morooka; Momoko Okasaki; Kimiteru Ito; Takuya Mitsumoto; Kazuhiko Nakajima; Takashi Sato; Makoto Mochizuki; Osamu Okazaki
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical nuclear medicine     Volume:  37     ISSN:  1536-0229     ISO Abbreviation:  Clin Nucl Med     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-07-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7611109     Medline TA:  Clin Nucl Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  807-9     Citation Subset:  IM    
Affiliation:
From the *Division of Nuclear Medicine, Department of Radiology, National Center for Global Health and Medicine; †Positron Medical Center, Tokyo Metropolitan Institute of Gerontology; ‡Department of Radiology, National Center of Neurology and Psychiatry; and §Division of Pathology, Departments of Central Laboratory and ∥Cardiology, National Center for Global Health and Medicine, Tokyo, Japan.
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