| Amyloid goiter and hypopituitarism in a patient with systemic amyloidosis. | |
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MedLine Citation:
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PMID: 21231858 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Systemic amyloidosis may infiltrate the thyroid or other endocrine glands but rarely causes endocrine dysfunction. We describe a 45 years old female patient with diffusely enlarged goiter and hypopituitarism secondary to amyloid infiltration of the thyroid gland and possibly pituitary gland, respectively. She was on chronic haemodialysis for 3 years due to systemic amyloidosis. While she was being prepared for thyroidectomy, adrenal failure developed. Her anterior pituitary hormone levels were low and magnetic resonance imaging of the hypophysis showed low signal intensity in right part of the adenohypophysis. She improved with corticosteroid replacement therapy and underwent subtotal thyroidectomy without any complication. Histopathologically, amyloid deposition was demonstrated in the thyroid gland. To our knowledge, this is the first case with amyloid goiter and hypopituitarism secondary to systemic amyloidosis. Amyloid infiltration should be considered in a systemic amyloidosis patient presenting with rapidly enlarged thyroid gland and signs of hypopituitarism. |
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Authors:
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Didem Ozdemir; Selcuk Dagdelen; Tomris Erbas; Cenk Sokmensuer; Belkis Erbas; Aysenur Cila |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-1-13 |
Journal Detail:
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Title: Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis Volume: - ISSN: 1744-2818 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-1-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9433802 Medline TA: Amyloid Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Endocrinology and Metabolism, School of Medicine, Hacettepe University, Ankara, Turkey. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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