| Amyloid-β associated volume loss occurs only in the presence of phospho-tau. | |
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MedLine Citation:
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PMID: 22002658 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The relationship between neurodegeneration and the 2 hallmark proteins of Alzheimer's disease, amyloid-β (Aβ) and tau, is still unclear. Here, we examined 286 nondemented participants (107 cognitively normal older adults and 179 memory impaired individuals) who underwent longitudinal magnetic resonance (MR) imaging and lumbar puncture. Using mixed effects models, we investigated the relationship between longitudinal entorhinal cortex atrophy rate, cerebrospinal fluid (CSF) p-tau(181p) and CSF Aβ(1-42) . We found a significant relationship between elevated entorhinal cortex atrophy rate and decreased CSF Aβ(1-42) only with elevated CSF p-tau(181p) . Our findings indicate that Aβ-associated volume loss occurs only in the presence of phospho-tau in humans at risk for dementia. |
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Authors:
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Rahul S Desikan; Linda K McEvoy; Wesley K Thompson; Dominic Holland; J Cooper Roddey; Kaj Blennow; Paul S Aisen; James B Brewer; Bradley T Hyman; Anders M Dale; |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-10-14 |
Journal Detail:
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Title: Annals of neurology Volume: 70 ISSN: 1531-8249 ISO Abbreviation: Ann. Neurol. Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-26 Completed Date: 2012-01-04 Revised Date: 2012-05-22 |
Medline Journal Info:
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Nlm Unique ID: 7707449 Medline TA: Ann Neurol Country: United States |
Other Details:
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Languages: eng Pagination: 657-61 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 American Neurological Association. |
Affiliation:
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Department of Radiology, University of California-San Diego, La Jolla 92037, CA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Amnesia / cerebrospinal fluid*, pathology Amyloid beta-Peptides / cerebrospinal fluid* Atrophy Cerebral Cortex / pathology* Female Humans Longitudinal Studies Male Mild Cognitive Impairment / cerebrospinal fluid*, pathology Peptide Fragments / cerebrospinal fluid* tau Proteins / cerebrospinal fluid* |
| Grant Support | |
ID/Acronym/Agency:
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AG030514/AG/NIA NIH HHS; K01 AG029218/AG/NIA NIH HHS; K01AG029218/AG/NIA NIH HHS; K02 NS067427/NS/NINDS NIH HHS; P30 AG010129/AG/NIA NIH HHS; R01AG031224/AG/NIA NIH HHS; T32 EB005970/EB/NIBIB NIH HHS; U01 AG024904/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Amyloid beta-Peptides; 0/Peptide Fragments; 0/amyloid beta-protein (1-42); 0/tau Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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