Document Detail

Amyloid light chain deposition associated with dermatofibroma: serendipity or association?
MedLine Citation:
PMID:  20110798     Owner:  NLM     Status:  MEDLINE    
Primary cutaneous amyloidosis, also known as nodular amyloidosis, is defined as deposition of amyloid light chain in the skin in the absence of a systemic cause of amyloidosis. Such amyloid is produced by a localized aggregate of clonal plasma cells. In contrast, secondary cutaneous amyloidosis is related to lesions such as squamous cell carcinoma, Bowen disease, basal cell carcinoma, and discoid lupus erythematosus, and has been shown in most cases to be derived from keratin epithelial elements. Herein, we present a unique case of nodular amyloidosis occurring in association with a cellular dermatofibroma.
Brian C Quigley; Jason Ricciuti; Michael B Morgan
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The American Journal of dermatopathology     Volume:  32     ISSN:  1533-0311     ISO Abbreviation:  Am J Dermatopathol     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-26     Completed Date:  2010-07-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7911005     Medline TA:  Am J Dermatopathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  298-300     Citation Subset:  IM    
Department of Pathology, University of South Florida, College of Medicine, Tampa, FL 33612, USA.
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MeSH Terms
Amyloid / analysis,  metabolism*
Diagnosis, Differential
Histiocytoma, Benign Fibrous / metabolism,  pathology*,  surgery
Immunoglobulin Light Chains / metabolism*
Lipoma / diagnosis
Middle Aged
Skin Neoplasms / metabolism,  pathology*,  surgery
Reg. No./Substance:
0/Amyloid; 0/Immunoglobulin Light Chains

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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