Document Detail


Amyloid-independent mechanisms in Alzheimer's disease pathogenesis.
MedLine Citation:
PMID:  21068297     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Despite the progress of the past two decades, the cause of Alzheimer's disease (AD) and effective treatments against it remain elusive. The hypothesis that amyloid-β (Aβ) peptides are the primary causative agents of AD retains significant support among researchers. Nonetheless, a growing body of evidence shows that Aβ peptides are unlikely to be the sole factor in AD etiology. Evidence that Aβ/amyloid-independent factors, including the actions of AD-related genes, also contribute significantly to AD pathogenesis was presented in a symposium at the 2010 Annual Meeting of the Society for Neuroscience. Here we summarize the studies showing how amyloid-independent mechanisms cause defective endo-lysosomal trafficking, altered intracellular signaling cascades, or impaired neurotransmitter release and contribute to synaptic dysfunction and/or neurodegeneration, leading to dementia in AD. A view of AD pathogenesis that encompasses both the amyloid-dependent and -independent mechanisms will help fill the gaps in our knowledge and reconcile the findings that cannot be explained solely by the amyloid hypothesis.
Authors:
Sanjay W Pimplikar; Ralph A Nixon; Nikolaos K Robakis; Jie Shen; Li-Huei Tsai
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  30     ISSN:  1529-2401     ISO Abbreviation:  J. Neurosci.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-11     Completed Date:  2010-12-13     Revised Date:  2014-09-22    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  14946-54     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Alzheimer Disease / etiology*,  pathology
Amyloid beta-Peptides
Humans
Lysosomes / pathology*
Neurons / pathology*
Protein Transport
Signal Transduction
Grant Support
ID/Acronym/Agency:
AG008200/AG/NIA NIH HHS; P01 AG017617/AG/NIA NIH HHS; P01-AG027916/AG/NIA NIH HHS; P01-AG17617/AG/NIA NIH HHS; R01 AG008200/AG/NIA NIH HHS; R01 AG026146/AG/NIA NIH HHS; R01 NS042818/NS/NINDS NIH HHS; R01 NS051874/NS/NINDS NIH HHS; R01-AG026146/AG/NIA NIH HHS; R01-NS041783/NS/NINDS NIH HHS; R01-NS042818/NS/NINDS NIH HHS; R01-NS051874/NS/NINDS NIH HHS; R37 AG017926/AG/NIA NIH HHS; R37 AG017926/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
0/Amyloid beta-Peptides
Comments/Corrections

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