Document Detail


Amylinergic control of food intake in lean and obese rodents.
MedLine Citation:
PMID:  21324327     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Obesity develops despite a complex and seemingly well orchestrated network that controls eating, energy expenditure and ultimately body weight; many of the involved signals are derived from the gastrointestinal tract. It is assumed that this network as an entity aims at maintaining body weight and body adiposity at a relatively constant level, but the control mechanisms seem to fail at least if an individual is chronically exposed to an oversupply of food. This article summarizes recent findings about the role of amylin in the control of eating in lean and obese rodents. The article gives some short background information about the well investigated adiposity and satiating signals leptin and cholecystokinin, respectively; this will provide the framework to discuss aspects of amylin physiology and pathophysiology in the control of eating in leanness and obesity. This discussion also involves the mechanisms mediating amylin's eating inhibitory effect in the area postrema and the interactions between amylin and leptin. Further, we discuss the effect of high fat diets on amylin release and amylin action in lean and obese rats. The last part of this article raises the question whether amylin interacts with the reward system in the forebrain.
Authors:
Christina N Boyle; Thomas A Lutz
Related Documents :
22763887 - Injuries from ingestion of wire bristles from grill-cleaning brushes - providence, rhod...
22467837 - Anaphylaxis: current state of knowledge for the modern physician.
10907227 - Magnesium transport from aqueous solutions across caco-2 cells--an experimental model f...
8439637 - Early evening nizatidine intake with a meal optimizes the antisecretory effect.
1965567 - Modulation of free radicals and superoxide dismutases by age and dietary restriction.
24768647 - Economics of food intake in mice: energy yield of the reinforcer.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-12
Journal Detail:
Title:  Physiology & behavior     Volume:  -     ISSN:  1873-507X     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-2-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2010. Published by Elsevier Inc.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Adolescent pre-exposure to ethanol or MDMA prolongs the conditioned rewarding effects of MDMA.
Next Document:  Oral Fatty acid signaling and intestinal lipid processing: Support and supposition.