| Amylin peptide levels are raised in infants of diabetic mothers. | |
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MedLine Citation:
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PMID: 16174639 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Amylin is a novel 37 amino acid peptide hormone that is co-secreted with insulin from the pancreas in response to food intake. As a potent inhibitor of gastric emptying it plays an important role in the control of carbohydrate absorption. Feed intolerance is common in infants of diabetic mothers (IDM). AIMS: To establish a normal range of amylin levels in healthy neonates, and to determine whether serum amylin levels are raised in IDM. METHODS: A serial sample of 221 infants > or =28 weeks gestation was enrolled prior to delivery over a 12 month period. Blood samples collected immediately after birth (umbilical cord), and at the routine Guthrie test were analysed for amylin and insulin levels. RESULTS: Amylin levels in umbilical cord (n = 181) and Guthrie samples (n = 33) of healthy infants were 5.7 (3.0-9.1) and 6.9 (2.9-9.0) pmol/l respectively. IDM had significantly raised amylin levels in both cord (n = 31; 32.7 pmol/l, 25.9-48.1) and Guthrie samples (n = 8; 18.1 pmol/l, 15.3-23.6). Amylin correlated positively with insulin (n = 42; r = 0.67; 95% CI 0.4 to 0.81), birth weight (r = 0.22; 95% CI 0.08 to 0.36), and gestation (r = 0.18; 95% CI 0.03 to 0.32). Umbilical cord venous amylin levels showed agreement with arterial cord amylin levels (n = 34, mean bias -0.2, 95% CI 3.1 to -3.6). CONCLUSIONS: Amylin levels are significantly increased in the umbilical cord and Guthrie blood samples in IDM. |
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Authors:
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V Kairamkonda; A Deorukhkar; R Coombs; R Fraser; T Mayer |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2005-09-20 |
Journal Detail:
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Title: Archives of disease in childhood Volume: 90 ISSN: 1468-2044 ISO Abbreviation: Arch. Dis. Child. Publication Date: 2005 Dec |
Date Detail:
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Created Date: 2005-11-22 Completed Date: 2006-01-05 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0372434 Medline TA: Arch Dis Child Country: England |
Other Details:
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Languages: eng Pagination: 1279-82 Citation Subset: AIM; IM |
Affiliation:
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Dept of Neonatal Intensive Care, Royal Hallamshire Hospital, Sheffield, UK. venkatash.kairamkonda@uhl-tr.nhs.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amyloid
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blood* Birth Weight Blood Specimen Collection / methods Diabetes Mellitus, Type 1 Diabetes Mellitus, Type 2 Diabetes, Gestational Female Fetal Blood / chemistry* Gestational Age Humans Infant, Newborn / blood* Insulin / blood Male Pregnancy Pregnancy in Diabetics* Reference Values |
| Chemical | |
Reg. No./Substance:
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0/Amyloid; 106602-62-4/amylin; 11061-68-0/Insulin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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