Document Detail

Amylin peptide levels are raised in infants of diabetic mothers.
MedLine Citation:
PMID:  16174639     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Amylin is a novel 37 amino acid peptide hormone that is co-secreted with insulin from the pancreas in response to food intake. As a potent inhibitor of gastric emptying it plays an important role in the control of carbohydrate absorption. Feed intolerance is common in infants of diabetic mothers (IDM). AIMS: To establish a normal range of amylin levels in healthy neonates, and to determine whether serum amylin levels are raised in IDM. METHODS: A serial sample of 221 infants > or =28 weeks gestation was enrolled prior to delivery over a 12 month period. Blood samples collected immediately after birth (umbilical cord), and at the routine Guthrie test were analysed for amylin and insulin levels. RESULTS: Amylin levels in umbilical cord (n = 181) and Guthrie samples (n = 33) of healthy infants were 5.7 (3.0-9.1) and 6.9 (2.9-9.0) pmol/l respectively. IDM had significantly raised amylin levels in both cord (n = 31; 32.7 pmol/l, 25.9-48.1) and Guthrie samples (n = 8; 18.1 pmol/l, 15.3-23.6). Amylin correlated positively with insulin (n = 42; r = 0.67; 95% CI 0.4 to 0.81), birth weight (r = 0.22; 95% CI 0.08 to 0.36), and gestation (r = 0.18; 95% CI 0.03 to 0.32). Umbilical cord venous amylin levels showed agreement with arterial cord amylin levels (n = 34, mean bias -0.2, 95% CI 3.1 to -3.6). CONCLUSIONS: Amylin levels are significantly increased in the umbilical cord and Guthrie blood samples in IDM.
V Kairamkonda; A Deorukhkar; R Coombs; R Fraser; T Mayer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-09-20
Journal Detail:
Title:  Archives of disease in childhood     Volume:  90     ISSN:  1468-2044     ISO Abbreviation:  Arch. Dis. Child.     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-11-22     Completed Date:  2006-01-05     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372434     Medline TA:  Arch Dis Child     Country:  England    
Other Details:
Languages:  eng     Pagination:  1279-82     Citation Subset:  AIM; IM    
Dept of Neonatal Intensive Care, Royal Hallamshire Hospital, Sheffield, UK.
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MeSH Terms
Amyloid / blood*
Birth Weight
Blood Specimen Collection / methods
Diabetes Mellitus, Type 1
Diabetes Mellitus, Type 2
Diabetes, Gestational
Fetal Blood / chemistry*
Gestational Age
Infant, Newborn / blood*
Insulin / blood
Pregnancy in Diabetics*
Reference Values
Reg. No./Substance:
0/Amyloid; 106602-62-4/amylin; 11061-68-0/Insulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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