Document Detail


Amylin and gastrointestinal activity.
MedLine Citation:
PMID:  9688456     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. Amylin is a new pancreatic islet peptide with a role in the maintenance of glucose homeostasis. 2. Amylin is predominantly present in the beta cells of the pancreas and to a lesser extent in the gastrointestinal tract and in the nervous system, where amylin mRNA is also present along with specific binding sites. 3. Amylin given peripherally or centrally inhibits acid gastric secretion in a dose-dependent manner and has a protective effect against indomethacin- or ethanol-induced ulcers only when injected centrally. 4. Subcutaneous or central injection of amylin produces a dose-dependent inhibition of gastric emptying, which may contribute to the activity of amylin in the regulation of carbohydrate absorption. In addition amylin inhibits food intake both when injected peripherally or centrally. 5. Amylin may thus be considered a novel brain-gut peptide taking part in the rapid endocrine response during digestion to maintain euglycemia.
Authors:
F Guidobono
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  General pharmacology     Volume:  31     ISSN:  0306-3623     ISO Abbreviation:  Gen. Pharmacol.     Publication Date:  1998 Aug 
Date Detail:
Created Date:  1998-10-22     Completed Date:  1998-10-22     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7602417     Medline TA:  Gen Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  173-7     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milan, Italy. francesca.guidobono@unimi.it
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MeSH Terms
Descriptor/Qualifier:
Amyloid / pharmacology,  physiology*
Animals
Anti-Ulcer Agents / pharmacology*
Digestive System Physiological Phenomena*
Gastric Acid / secretion
Gastric Emptying
Glucose / metabolism*
Homeostasis
Humans
Stomach Ulcer / drug therapy
Chemical
Reg. No./Substance:
0/Amyloid; 0/Anti-Ulcer Agents; 106602-62-4/amylin; 50-99-7/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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