Document Detail

Amylase-producing multiple myeloma. Cytochemical, immunohistochemical and immunoelectron microscopic studies.
MedLine Citation:
PMID:  2474886     Owner:  NLM     Status:  MEDLINE    
The first autopsy case of amylase-producing IgA-lambda-type multiple myeloma is described. Immunohistochemically, amylase and alpha and lambda chains of immunoglobulin were demonstrated in the cytoplasm of the myeloma cells. Secretion of amylase by cultured myeloma cells obtained from the patient's pleural effusion was clearly demonstrated by the starch film method. Immunoelectron microscopically, positive reaction products for amylase and the alpha chain of immunoglobulin were observed in the well developed endoplasmic reticulum. Since no secretory granules were observed, we postulated that the secretory process of amylase was not via the zymogen granules but via a mechanism similar to that for immunoglobulin.
M Takeya; H Matsuzaki; H Hata; K Takatsuki; K Takahashi
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Virchows Archiv. A, Pathological anatomy and histopathology     Volume:  415     ISSN:  0174-7398     ISO Abbreviation:  Virchows Arch A Pathol Anat Histopathol     Publication Date:  1989  
Date Detail:
Created Date:  1989-09-15     Completed Date:  1989-09-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8302198     Medline TA:  Virchows Arch A Pathol Anat Histopathol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  219-24     Citation Subset:  IM    
Second Department of Pathology, Kumamoto University Medical School, Japan.
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MeSH Terms
Amylases / metabolism*
Immunoglobulin A, Secretory / metabolism
Microscopy, Electron
Middle Aged
Multiple Myeloma / metabolism*,  pathology,  ultrastructure
Saliva / immunology
Reg. No./Substance:
0/Immunoglobulin A, Secretory; EC 3.2.1.-/Amylases

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