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Amygdalin induces apoptosis in human cervical cancer cell line HeLa cells.
MedLine Citation:
PMID:  23137229     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Amygdalin, a naturally occurring substance, has been suggested to be efficacious as an anticancer substance. The effect of amygdalin on cervical cancer cells has never been studied. In this study, we found that the viability of human cervical cancer HeLa cell line was significantly inhibited by amygdalin. 4,6-Diamino-2-phenyl indole (DAPI) staining showed that amygdalin-treated HeLa cells developed typical apoptotic changes. The development of apoptosis in the amygdalin-treated HeLa cells were confirmed by double staining of amygdalin-treated HeLa cells with annexin V-FITC and propidium iodide (PI) along with increase in caspase-3 activity in these cells. Further studies indicated that antiapoptotic protein Bcl-2 was downregulated whereas proapoptotic Bax protein was upregulated in the amygdalin-treated HeLa cells implying involvement of the intrinsic pathway of apoptosis. In vivo, amygdalin administration inhibited the growth of HeLa cell xenografts through a mechanism of apoptosis. The results in the present study suggest that amygdalin may offer a new therapeutic option for patients with cervical cancer.
Authors:
Yu Chen; Jinshu Ma; Fang Wang; Jie Hu; Ai Cui; Chengguo Wei; Qing Yang; Fan Li
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Immunopharmacology and immunotoxicology     Volume:  35     ISSN:  1532-2513     ISO Abbreviation:  Immunopharmacol Immunotoxicol     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2012-11-09     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8800150     Medline TA:  Immunopharmacol Immunotoxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  43-51     Citation Subset:  IM    
Affiliation:
Department of Pathogenobiology, Bethune College of Medicine, Jilin University , Chang Chun, Jilin , China.
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