| Amygdalar enlargement in patients with temporal lobe epilepsy. | |
| | |
MedLine Citation:
|
PMID: 21047879 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Objective The purpose of the study was to clarify the significance of amygdalar enlargement (AE) in patients with temporal lobe epilepsy (TLE) detected by MRI. Methods 11 TLE patients (eight men, mean age 45.3 (SD 18.2) years) with AE treated at Kyoto University Hospital were studied. Clinical history, ictal semiology, EEG, fluorodeoxyglucose-positron emission tomography (FDG-PET), interictal single photon emission CT (SPECT) and MRI were investigated. Amygdalar volume measured by 3 T MRI and its laterality index (LI) were compared with the three other groups: normal controls, patients with partial epilepsy of non-TLE and mesial TLE with hippocampal sclerosis (HS). Results Average age of onset was 39.8 years (SD 19.5). Eight had complex partial seizures and three had generalised seizures. Epileptiform discharges were found in the temporal area ipsilateral to the AE by EEG. Interictal FDG-PET/SPECT revealed regional hypometabolism or hypoperfusion in the ipsilateral temporal area. MRI showed AE on the right in five patients, on the left in five and bilateral in one, all without apparent HS. Ten of 11 patients were diagnosed as unilateral TLE ipsilateral to the AE by neurophysiological and neuroimaging methods. Enlarged amygdalae showed iso- to slightly high intensity in FLAIR images without enhancement. Unilateral AE was not seen in the other three groups for amygdalar volume and LI (p<0.05). Discussion AE is most likely a subtype of TLE without ipsilateral HS. This possibility of AE should be considered in TLE patients if there is no apparent HS. |
| | |
Authors:
|
Takahiro Mitsueda-Ono; Akio Ikeda; Morito Inouchi; Shigetoshi Takaya; Riki Matsumoto; Takashi Hanakawa; Nobukatsu Sawamoto; Nobuhiro Mikuni; Hidenao Fukuyama; Ryosuke Takahashi |
Related Documents
:
|
2141849 - Visual illusions associated with previous drug abuse. 15337129 - Early post-operative seizures after burr-hole drainage for chronic subdural hematoma: c... 16406729 - The role of fdg-pet, ictal spect, and meg in the epilepsy surgery evaluation. 2302439 - Temporal lobe abnormalities in panic disorder: an mri study. 7791949 - Band brain heterotopia. case report and literature review. 17947049 - Spatio-temporal source localization and granger causality in ictal source analysis. 9324129 - Value of helical computed tomography, angiography, and endoscopic ultrasound in determi... 9783789 - Magnetic resonance imaging differentiates between necrotizing and non-necrotizing fasci... 11686279 - Influence of ct contrast agents on dose calculations in a 3d treatment planning system. |
Publication Detail:
|
Type: Journal Article Date: 2010-11-03 |
Journal Detail:
|
Title: Journal of neurology, neurosurgery, and psychiatry Volume: 82 ISSN: 1468-330X ISO Abbreviation: J. Neurol. Neurosurg. Psychiatr. Publication Date: 2011 Jun |
Date Detail:
|
Created Date: 2011-05-09 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 2985191R Medline TA: J Neurol Neurosurg Psychiatry Country: England |
Other Details:
|
Languages: eng Pagination: 652-7 Citation Subset: IM |
Affiliation:
|
Department of Neurology, Kyoto University Hospital, 54 Shogoin-Kawaharacho, Sakyo-ku, Kyoto 606-8507, Japan; akio@kuhp.kyoto-u.ac.jp. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Rate of familial amyotrophic lateral sclerosis: a systematic review and meta-analysis.
Next Document: Vitamin D metabolites are associated with clinical and MRI outcomes in multiple sclerosis patients.