Document Detail

Amrinone: pharmacokinetics and pharmacodynamics.
MedLine Citation:
PMID:  2521045     Owner:  NLM     Status:  MEDLINE    
Amrinone is a selective inhibitor of phosphodiesterase fraction 3 in both cardiac and smooth muscle. Intravenous administration in humans produces increased contractility and vasodilation of venous capacitance and arterial conductance vessels. The elimination half-life in healthy patients is reported to be 2.6 to 4.1 hours, making it the only long-acting positive inotropic agent available that can be administered either as an intravenous bolus or by infusion. A low incidence of side effects, often minor, has been reported with intravenous use. Thrombocytopenia does not seem to be a problem with short-term use. Amrinone represents a new approach in the pharmacologic therapy for ventricular dysfunction following cardiac surgery.
J H Levy; J M Bailey
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of cardiothoracic anesthesia     Volume:  3     ISSN:  0888-6296     ISO Abbreviation:  J Cardiothorac Anesth     Publication Date:  1989 Dec 
Date Detail:
Created Date:  1992-08-18     Completed Date:  1992-08-18     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8709732     Medline TA:  J Cardiothorac Anesth     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  10-4     Citation Subset:  IM    
Division of Cardiothoracic Anesthesiology, Emory University School of Medicine, Emory University Hospital, Atlanta, GA 30322.
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MeSH Terms
Amrinone / administration & dosage,  pharmacokinetics*,  pharmacology*
Drug Combinations
Reg. No./Substance:
0/Drug Combinations; 60719-84-8/Amrinone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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