| Amrinone increases ventricular contractility and diastolic compliance in endotoxemia. | |
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MedLine Citation:
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PMID: 7633698 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Systolic and diastolic dysfunction occur during human septic shock, and sensitivity to beta-adrenergic agents is reduced. We sought to determine whether amrinone, an inotropic agent independent of beta-receptors, increases left-ventricular contractility or diastolic compliance after endotoxin infusion. We measured left-ventricular volume (using a conductance catheter) and pressure (using a Millar catheter) before and after administering amrinone (4.5 mg/kg i.v., then 10 micrograms/kg/min) to six endotoxemic and seven control pigs. The slope of the end-systolic pressure-volume relationship, Ees, was used as the primary measure of contractility. Diastolic stiffness was characterized using stiffness parameters taken from pressure-volume relationships (k) and from pressure-volume strain relationships. Amrinone increased Ees from a median of 10.4 mm Hg/ml (interquartile range, 7.2 to 12.3) to 16.4 (13.7 to 18.6) (p < 0.05) in the endotoxin group (p < 0.05). Amrinone decreased diastolic stiffness (k) in the endotoxin group by 35 +/- 18% (p < 0.05). Amrinone did not significantly change Ees or k in the control group. Mean arterial pressure decreased after endotoxin infusion from 117 +/- 23 mm Hg to 76.5 +/- 14.9 mm Hg (p < 0.05), and decreased further after amrinone to 62.0 +/- 14.8 mm Hg (p < 0.05). We conclude that in this model of sepsis, amrinone may beneficially increase systolic contractility and diastolic compliance, but may dangerously decrease an already low mean arterial pressure. |
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Authors:
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H A Werner; M J Herbertson; K R Walley |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of respiratory and critical care medicine Volume: 152 ISSN: 1073-449X ISO Abbreviation: Am. J. Respir. Crit. Care Med. Publication Date: 1995 Aug |
Date Detail:
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Created Date: 1995-09-14 Completed Date: 1995-09-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9421642 Medline TA: Am J Respir Crit Care Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 496-503 Citation Subset: AIM; IM |
Affiliation:
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Pulmonary Research Laboratory, St. Paul's Hospital, University of British Columbia, Vancouver, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amrinone
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pharmacology* Animals Atrial Function, Right / drug effects Blood Pressure / drug effects Cardiac Output / drug effects Cardiac Volume / drug effects Coronary Circulation / drug effects Diastole Elasticity Endotoxins / blood* Escherichia coli Heart Catheterization Heart Rate / drug effects Myocardial Contraction / drug effects* Oxygen / blood Shock, Septic / physiopathology* Stroke Volume / drug effects Swine Systole Ventricular Function, Left / drug effects* Ventricular Pressure / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Endotoxins; 60719-84-8/Amrinone; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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