| Amputation-induced reactive oxygen species are required for successful Xenopus tadpole tail regeneration. | |
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MedLine Citation:
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PMID: 23314862 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Understanding the molecular mechanisms that promote successful tissue regeneration is critical for continued advancements in regenerative medicine. Vertebrate amphibian tadpoles of the species Xenopus laevis and Xenopus tropicalis have remarkable abilities to regenerate their tails following amputation, through the coordinated activity of numerous growth factor signalling pathways, including the Wnt, Fgf, Bmp, Notch and TGF-β pathways. Little is known, however, about the events that act upstream of these signalling pathways following injury. Here, we show that Xenopus tadpole tail amputation induces a sustained production of reactive oxygen species (ROS) during tail regeneration. Lowering ROS levels, using pharmacological or genetic approaches, reduces the level of cell proliferation and impairs tail regeneration. Genetic rescue experiments restored both ROS production and the initiation of the regenerative response. Sustained increased ROS levels are required for Wnt/β-catenin signalling and the activation of one of its main downstream targets, fgf20 (ref. ), which, in turn, is essential for proper tail regeneration. These findings demonstrate that injury-induced ROS production is an important regulator of tissue regeneration. |
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Authors:
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Nick R Love; Yaoyao Chen; Shoko Ishibashi; Paraskevi Kritsiligkou; Robert Lea; Yvette Koh; Jennifer L Gallop; Karel Dorey; Enrique Amaya |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-13 |
Journal Detail:
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Title: Nature cell biology Volume: - ISSN: 1476-4679 ISO Abbreviation: Nat. Cell Biol. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100890575 Medline TA: Nat Cell Biol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1] Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK [2] The Healing Foundation Centre, Michael Smith Building, University of Manchester, Oxford Road, Manchester M13 9PT, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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