Document Detail

Amputation for acute ischaemia is associated with increased comorbidity and higher amputation level.
MedLine Citation:
PMID:  12664046     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: There is some evidence that the early outcome of major amputation is worse after failed thromboembolectomy, but the risk factors and results of amputation done for acute ischaemia have never been compared with those for chronic ischaemia in a large series of patients. METHOD: Retrospective review of 30 day outcome for all 322 primary amputations done for arterial disease during 1992-8. There were 286 patients (163 male; median age 76 years) who had 270 amputations for chronic ischaemia and 52 for acute ischaemia. RESULTS: The acute group had higher prevalences of cardiac disease (48% versus 29%-p<0.02), limiting pulmonary disease (27% versus 13%-p<0.02) and ASA grades 4 and 5 (27% versus 14%-p<0.05). Amputation below the knee was less common after acute ischaemia (31% versus 60%-p<0.001). There were trends towards more revisions (19% versus 11%) and higher mortality (25% versus 19%) in the acute group but neither reached statistical significance. CONCLUSION: Patients having major amputations for acute ischaemia have higher levels of pre-existing comorbidity than those with chronic ischaemia and are twice as likely to require amputation above the knee. They should be managed as a particularly high risk group.
W B Campbell; S Marriott; R Eve; E Mapson; S Sexton; J F Thompson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cardiovascular surgery (London, England)     Volume:  11     ISSN:  0967-2109     ISO Abbreviation:  Cardiovasc Surg     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-03-28     Completed Date:  2003-07-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9308765     Medline TA:  Cardiovasc Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  121-3     Citation Subset:  IM    
Department of Surgery, Royal Devon and Exeter Hospital, UK.
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MeSH Terms
Acute Disease
Aged, 80 and over
Amputation / methods*
Chronic Disease
Heart Diseases / complications
Ischemia / complications,  surgery*
Leg / blood supply*
Lung Diseases / complications
Middle Aged
Retrospective Studies
Risk Factors
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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