Document Detail

Ampulla (Takotsubo) cardiomyopathy caused by secondary adrenal insufficiency in ACTH isolated deficiency.
MedLine Citation:
PMID:  17664847     Owner:  NLM     Status:  MEDLINE    
We describe here a case of reversible ampulla (takotsubo) cardiomyopathy caused by secondary adrenal insufficiency in ACTH isolated deficiency. A 53-year-old woman was referred to our department for evaluation and treatment of unconsciousness. On admission, her plasma glucose level was 34 mg/dL, suggesting loss of consciousness due to hypoglycemia. Basal levels of ACTH, cortisol, and dehydroepiandrosterone sulfate in blood, and urinary free cortisol levels were all decreased. ACTH and cortisol levels were not adequately increased in response to CRH administration and the insulin tolerance test. Electrocardiography showed ST segment elevation and T wave inversion in leads V 1-6. The coronary arteries were free of organic stenosis, and a left ventriculogram revealed severe hypokinesis, particularly in the anterior and posterior walls. Based on a diagnosis of adrenocortical insufficiency caused by ACTH isolated deficiency, hydrocortisone was administered. Two weeks after treatment, ultrasound studies of the heart showed recovery of left ventricular wall motion. Activation of the sympathetic nervous system, adrenocortical failure, and hypoglycemic attack were considered to be triggering factors for the takotsubo cardiomyopathy. Careful monitoring of cardiac function and appropriate treatments for both cardiomyopathy and adrenocortical failure are required to recover cardiac dysfunction.
Satoru Sakihara; Kazunori Kageyama; Takeshi Nigawara; Yukie Kidani; Toshihiro Suda
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2007-07-31
Journal Detail:
Title:  Endocrine journal     Volume:  54     ISSN:  0918-8959     ISO Abbreviation:  Endocr. J.     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-09-19     Completed Date:  2008-01-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9313485     Medline TA:  Endocr J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  631-6     Citation Subset:  IM    
Department of Endocrinology and Metabolism, Hirosaki University School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori 036-8562, Japan.
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MeSH Terms
Adrenal Insufficiency / complications*
Adrenocorticotropic Hormone / blood,  deficiency*
Hydrocortisone / blood
Middle Aged
Radionuclide Ventriculography
Takotsubo Cardiomyopathy / diagnosis,  etiology*
Ventricular Dysfunction, Left / diagnosis,  etiology
Reg. No./Substance:
50-23-7/Hydrocortisone; 9002-60-2/Adrenocorticotropic Hormone

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