| Amplitude and frequency dependence of spike timing: implications for dynamic regulation. | |
MedLine Citation:
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PMID: 12634276 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The spike-time reliability of motoneurons in the Aplysia buccal motor ganglion was studied as a function of the frequency content and the relative amplitude of the fluctuations in the neuronal input, calculated as the coefficient of variation (CV). Measurements of spike-time reliability to sinusoidal and aperiodic inputs, as well as simulations of a noisy leaky integrate-and-fire neuron stimulated by spike trains drawn from a periodically modulated process, demonstrate that there are three qualitatively different CV-dependent mechanisms that determine reliability: noise-dominated (CV < 0.05 for Aplysia motoneurons) where spike timing is unreliable regardless of frequency content; resonance-dominated (CV approximately 0.05-0.25) where reliability is reduced by removal of input frequencies equal to motoneuron firing rate; and amplitude-dominated (CV >0.35) where reliability depends on input frequencies greater than motoneuron firing rate. In the resonance-dominated regime, changes in the activity of the presynaptic inhibitory interneuron B4/5 alter motoneuron spike-time reliability. The increases or decreases in reliability occur coincident with small changes in motoneuron spiking rate due to changes in interneuron activity. Injection of a hyperpolarizing current into the motoneuron reproduces the interneuron-induced changes in reliability. The rate-dependent changes in reliability can be understood from the phase-locking properties of regularly spiking motoneurons to periodic inputs. Our observations demonstrate that the ability of a neuron to support a spike-time code can be actively controlled by varying the properties of the neuron and its input. |
Authors:
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John D Hunter; John G Milton |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. Date: 2003-03-12 |
Journal Detail:
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Title: Journal of neurophysiology Volume: 90 ISSN: 0022-3077 ISO Abbreviation: J. Neurophysiol. Publication Date: 2003 Jul |
Date Detail:
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Created Date: 2003-07-04 Completed Date: 2003-09-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375404 Medline TA: J Neurophysiol Country: United States |
Other Details:
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Languages: eng Pagination: 387-94 Citation Subset: IM |
Affiliation:
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Department of Neurology, University of Chicago, Chicago, Illinois 60615, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials* Animals Aplysia Interneurons Motor Neurons / physiology* Neural Inhibition Poisson Distribution Reproducibility of Results Synaptic Transmission |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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