Document Detail


Amplitude and frequency dependence of spike timing: implications for dynamic regulation.
MedLine Citation:
PMID:  12634276     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The spike-time reliability of motoneurons in the Aplysia buccal motor ganglion was studied as a function of the frequency content and the relative amplitude of the fluctuations in the neuronal input, calculated as the coefficient of variation (CV). Measurements of spike-time reliability to sinusoidal and aperiodic inputs, as well as simulations of a noisy leaky integrate-and-fire neuron stimulated by spike trains drawn from a periodically modulated process, demonstrate that there are three qualitatively different CV-dependent mechanisms that determine reliability: noise-dominated (CV < 0.05 for Aplysia motoneurons) where spike timing is unreliable regardless of frequency content; resonance-dominated (CV approximately 0.05-0.25) where reliability is reduced by removal of input frequencies equal to motoneuron firing rate; and amplitude-dominated (CV >0.35) where reliability depends on input frequencies greater than motoneuron firing rate. In the resonance-dominated regime, changes in the activity of the presynaptic inhibitory interneuron B4/5 alter motoneuron spike-time reliability. The increases or decreases in reliability occur coincident with small changes in motoneuron spiking rate due to changes in interneuron activity. Injection of a hyperpolarizing current into the motoneuron reproduces the interneuron-induced changes in reliability. The rate-dependent changes in reliability can be understood from the phase-locking properties of regularly spiking motoneurons to periodic inputs. Our observations demonstrate that the ability of a neuron to support a spike-time code can be actively controlled by varying the properties of the neuron and its input.
Authors:
John D Hunter; John G Milton
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.     Date:  2003-03-12
Journal Detail:
Title:  Journal of neurophysiology     Volume:  90     ISSN:  0022-3077     ISO Abbreviation:  J. Neurophysiol.     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-07-04     Completed Date:  2003-09-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375404     Medline TA:  J Neurophysiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  387-94     Citation Subset:  IM    
Affiliation:
Department of Neurology, University of Chicago, Chicago, Illinois 60615, USA.
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MeSH Terms
Descriptor/Qualifier:
Action Potentials*
Animals
Aplysia
Interneurons
Motor Neurons / physiology*
Neural Inhibition
Poisson Distribution
Reproducibility of Results
Synaptic Transmission

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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