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Amplified env and gag products on AKR cells. Origin from different murine leukemia virus genomes.
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MedLine Citation:
PMID:  6246188     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Thymocytes of AKR mice express two species of gp70, the envelope glycoprotein of murine leukemia virus (MuLV), encoded by the env gene. One is denoted Ec+ gp70 in reference to the type-antigen Ec and association with ecotropic virus. The other, Ec- gp70, resembles gp70 found also on thymocytes of mouse strains that are not overt producers of MuLV, and has no evident relation to ecotropic virus. Expression of Ec- gp70 type, but not of Ec+ gp70 type, is amplified with age on AKR thymocytes. In contrast, viral core polyproteins, encoded by the gag gene and simultaneously amplified with age, appear to be related to ecotropic virus. These observations imply selective amplification of products of env and gag genes from two sorts of provirus, a phenomenon which may be connected to the dual genetic origin of recombinant mink-cell-focus inducing viruses in AKR mice.
Authors:
J S Tung; E Fleissner
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of experimental medicine     Volume:  151     ISSN:  0022-1007     ISO Abbreviation:  J. Exp. Med.     Publication Date:  1980 Apr 
Date Detail:
Created Date:  1980-07-22     Completed Date:  1980-07-22     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985109R     Medline TA:  J Exp Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  975-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Genes, Viral*
Glycoproteins / biosynthesis,  genetics
Leukemia Virus, Murine / genetics*
Membrane Proteins / biosynthesis,  genetics
Mice
Mice, Inbred AKR / microbiology*
Peptide Fragments / analysis
Viral Proteins / biosynthesis,  genetics*
Chemical
Reg. No./Substance:
0/Glycoproteins; 0/Membrane Proteins; 0/Peptide Fragments; 0/Viral Proteins
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): J Exp Med
ISSN: 0022-1007
ISSN: 1540-9538
Publisher: The Rockefeller University Press
Article Information
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Print publication date: Day: 1 Month: 4 Year: 1980
Volume: 151 Issue: 4
First Page: 975 Last Page: 979
ID: 2185837
Publisher Id: 80183866
PubMed Id: 6246188

Amplified env and gag products on AKR cells. Origin from different murine leukemia virus genomes


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