Document Detail

Amplification and loss of repeat units of the human minisatellite MS1 integrated in chromosome III of a haploid yeast strain.
MedLine Citation:
PMID:  8479438     Owner:  NLM     Status:  MEDLINE    
Minisatellites comprise arrays of tandemly repeated short DNA sequences which show extensive variation in repeat unit number. The mechanisms that underlie this length variation are not understood. In order to study processes influencing length changes of minisatellites, we integrated the human minisatellite MS1 into a haploid strain of the yeast Saccharomyces cerevisiae. Frequent spontaneous generation of MS1 alleles with new lengths were observed in this yeast strain. Hence it is concluded that recombination between members of a pair of homologous chromosomes is not a prerequisite for the generation of length changes in MS1 in yeast.
H Cederberg; E Agurell; M Hedenskog; U Rannug
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Molecular & general genetics : MGG     Volume:  238     ISSN:  0026-8925     ISO Abbreviation:  Mol. Gen. Genet.     Publication Date:  1993 Apr 
Date Detail:
Created Date:  1993-05-26     Completed Date:  1993-05-26     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0125036     Medline TA:  Mol Gen Genet     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  38-42     Citation Subset:  IM    
Department of Genetic and Cellular Toxicology, Wallenberg Laboratory, Stockholm University, Sweden.
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MeSH Terms
Base Sequence
Blotting, Southern
Chromosomes, Fungal*
DNA, Fungal / genetics,  isolation & purification
DNA, Satellite / genetics*
Escherichia coli / genetics
Gene Amplification
Genetic Variation
Repetitive Sequences, Nucleic Acid*
Restriction Mapping
Saccharomyces cerevisiae / genetics*
Transformation, Genetic
Reg. No./Substance:
0/DNA, Fungal; 0/DNA, Satellite

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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