Document Detail

Amphotericin B: an update.
MedLine Citation:
PMID:  8757689     Owner:  NLM     Status:  MEDLINE    
Amphotericin B is the most important clinically and best defined chemically of the macrolide heptaene antibiotics. A fermentation product of the soil actinomycetes Streptomyces nodosus, amphotericin B binds selectively to ergosterol in the cell membrane of susceptible fungi, inducing changes in permeability that can produce lethal cell injury. Available since 1960, amphotericin B remains the treatment of choice for most serious systemic fungal infections. This review highlights some important aspects of the physicochemical properties of amphotericin B and their utilisation in its quantitative determination in biological fluids. Its mechanism of action is re-appraised in the light of recent results with regard to its effects on the physical and functional properties of synthetic and natural membranes. Attempts to reduce its toxic effects to host cells and to improve its therapeutic index are evaluated. In addition, the therapeutic values of amphotericin B, apart from its antibiotic activity, are discussed.
K M Abu-Salah
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  British journal of biomedical science     Volume:  53     ISSN:  0967-4845     ISO Abbreviation:  Br. J. Biomed. Sci.     Publication Date:  1996 Jun 
Date Detail:
Created Date:  1996-10-22     Completed Date:  1996-10-22     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9309208     Medline TA:  Br J Biomed Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  122-33     Citation Subset:  IM    
Department of Biochemistry, King Saud University, Riyadh, Saudi Arabia.
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MeSH Terms
Amphotericin B / chemistry,  pharmacology,  therapeutic use*
Antifungal Agents / chemistry,  pharmacology,  therapeutic use*
Drug Carriers
Drug Synergism
Immune System / drug effects
Reg. No./Substance:
0/Antifungal Agents; 0/Drug Carriers; 0/Liposomes; 1397-89-3/Amphotericin B

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