Document Detail

Amphotericin B tissue distribution in autopsy material after treatment with liposomal amphotericin B and amphotericin B colloidal dispersion.
MedLine Citation:
PMID:  16627591     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Tissue concentrations of amphotericin B were determined in autopsy material of patients who had been treated with liposomal amphotericin B or amphotericin B colloidal dispersion (colloidal amphotericin B) for suspected or proven invasive fungal infection. PATIENTS AND METHODS: Amphotericin B tissue levels were measured in liver, spleen, lung, kidney, and myocardial and brain tissue of 20 patients who had been treated with lipid-formulated amphotericin B, before they died from multi-organ failure. Seven patients had been treated with liposomal amphotericin B (AmBisome) and thirteen with colloidal amphotericin B (Amphocil). Tissue samples were obtained during routine autopsy, homogenized and extracted with methanol. Amphotericin B concentrations were measured using HPLC after purification by solid phase extraction. RESULTS: The highest amphotericin B levels were found in liver and spleen, followed by kidney, lung, myocardium and brain. In the lung higher amphotericin B concentrations were found after treatment with amphotericin B colloidal dispersion than after therapy with liposomal amphotericin B. CONCLUSIONS: The choice of lipid formulation may influence amphotericin B penetration into the lung.
Helene Vogelsinger; Stefan Weiler; Angela Djanani; Jordan Kountchev; Rosa Bellmann-Weiler; Christian J Wiedermann; Romuald Bellmann
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-04-20
Journal Detail:
Title:  The Journal of antimicrobial chemotherapy     Volume:  57     ISSN:  0305-7453     ISO Abbreviation:  J. Antimicrob. Chemother.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-05-24     Completed Date:  2006-10-03     Revised Date:  2008-09-25    
Medline Journal Info:
Nlm Unique ID:  7513617     Medline TA:  J Antimicrob Chemother     Country:  England    
Other Details:
Languages:  eng     Pagination:  1153-60     Citation Subset:  IM    
Clinical Pharmacokinetics Unit, Laboratory of Inflammation Research, Division of General Internal Medicine, Department of Internal Medicine, Innsbruck Medical School, Anichstrasse 35, A-6020 Innsbruck, Austria.
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MeSH Terms
Amphotericin B / analysis*,  pharmacokinetics
Brain Chemistry
Chromatography, High Pressure Liquid
Kidney / chemistry
Liver / chemistry
Lung / chemistry
Middle Aged
Multiple Organ Failure
Mycoses / complications,  drug therapy
Myocardium / chemistry
Spleen / chemistry
Tissue Distribution
Tissue Extracts / chemistry,  isolation & purification
Reg. No./Substance:
0/Tissue Extracts; 0/liposomal amphotericin B; 1397-89-3/Amphotericin B

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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