| Amphotericin B tissue distribution in autopsy material after treatment with liposomal amphotericin B and amphotericin B colloidal dispersion. | |
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MedLine Citation:
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PMID: 16627591 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Tissue concentrations of amphotericin B were determined in autopsy material of patients who had been treated with liposomal amphotericin B or amphotericin B colloidal dispersion (colloidal amphotericin B) for suspected or proven invasive fungal infection. PATIENTS AND METHODS: Amphotericin B tissue levels were measured in liver, spleen, lung, kidney, and myocardial and brain tissue of 20 patients who had been treated with lipid-formulated amphotericin B, before they died from multi-organ failure. Seven patients had been treated with liposomal amphotericin B (AmBisome) and thirteen with colloidal amphotericin B (Amphocil). Tissue samples were obtained during routine autopsy, homogenized and extracted with methanol. Amphotericin B concentrations were measured using HPLC after purification by solid phase extraction. RESULTS: The highest amphotericin B levels were found in liver and spleen, followed by kidney, lung, myocardium and brain. In the lung higher amphotericin B concentrations were found after treatment with amphotericin B colloidal dispersion than after therapy with liposomal amphotericin B. CONCLUSIONS: The choice of lipid formulation may influence amphotericin B penetration into the lung. |
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Authors:
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Helene Vogelsinger; Stefan Weiler; Angela Djanani; Jordan Kountchev; Rosa Bellmann-Weiler; Christian J Wiedermann; Romuald Bellmann |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-04-20 |
Journal Detail:
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Title: The Journal of antimicrobial chemotherapy Volume: 57 ISSN: 0305-7453 ISO Abbreviation: J. Antimicrob. Chemother. Publication Date: 2006 Jun |
Date Detail:
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Created Date: 2006-05-24 Completed Date: 2006-10-03 Revised Date: 2008-09-25 |
Medline Journal Info:
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Nlm Unique ID: 7513617 Medline TA: J Antimicrob Chemother Country: England |
Other Details:
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Languages: eng Pagination: 1153-60 Citation Subset: IM |
Affiliation:
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Clinical Pharmacokinetics Unit, Laboratory of Inflammation Research, Division of General Internal Medicine, Department of Internal Medicine, Innsbruck Medical School, Anichstrasse 35, A-6020 Innsbruck, Austria. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Amphotericin B / analysis*, pharmacokinetics Autopsy Brain Chemistry Chromatography, High Pressure Liquid Female Humans Kidney / chemistry Liver / chemistry Lung / chemistry Male Middle Aged Multiple Organ Failure Mycoses / complications, drug therapy Myocardium / chemistry Spleen / chemistry Tissue Distribution Tissue Extracts / chemistry, isolation & purification |
| Chemical | |
Reg. No./Substance:
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0/Tissue Extracts; 0/liposomal amphotericin B; 1397-89-3/Amphotericin B |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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