Document Detail


Amphotericin B lipid complex for Hansenula anomala pneumonia.
MedLine Citation:
PMID:  11816259     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To document the first successful treatment of a patient with Hansenula anomala pneumonia. CASE SUMMARY: A healthy 32-year-old white man who underwent splenectomy and aortic repair following a motor vehicle accident developed a life-threatening infection 2 days after admission into the intensive care unit (ICU). A rare fungus, H. anomala, was isolated from his lungs, blood, and urine. Lipid complex amphotericin B (ABLC) was initiated following worsening signs of infection complicated by renal failure. The patient received ABLC for 17 days, eventually making a full recovery, allowing ICU discharge 1 month after admission. DISCUSSION: This case represents the first successful treatment of H. anomala pneumonia reported in the literature. H. anomala infections typically occur in immunocompromised, neonatal, or pediatric populations in extrapulmonary sites. All 6 cases of H. anomala pneumonia reported in the literature were fatal, and all preceded the availability of ABLC. This case of H. anomala pneumonia is unique because our adult patient survived possibly due to the availability of aggressive treatment. CONCLUSIONS: ABLC may be the agent of choice for treatment of H. anomala infections, particularly in patients with acute renal failure.
Authors:
Sandra L Kane; Joseph F Dasta; Charles H Cook
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Annals of pharmacotherapy     Volume:  36     ISSN:  1060-0280     ISO Abbreviation:  Ann Pharmacother     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2002-01-30     Completed Date:  2002-07-12     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9203131     Medline TA:  Ann Pharmacother     Country:  United States    
Other Details:
Languages:  eng     Pagination:  59-62     Citation Subset:  IM    
Affiliation:
College of Pharmacy, Ohio State University, 500 W. 12th Ave., Columbus, OH 43210, USA. dasta.1@osu.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Amphotericin B / administration & dosage,  therapeutic use*
Antifungal Agents / administration & dosage,  therapeutic use*
Aorta / surgery
Humans
Liposomes
Male
Pichia*
Pneumonia / drug therapy*
Postoperative Complications / drug therapy
Splenectomy
Sputum / microbiology
Chemical
Reg. No./Substance:
0/Antifungal Agents; 0/Liposomes; 1397-89-3/Amphotericin B

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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